Influence of trust on the acceptance of the RTS,S malaria vaccine in the Kassena-Nankana districts of Ghana.

Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE

Original Publication: London : BioMed Central, [2002-

Malaria Vaccines*/administration & dosage ; Trust*; Ghana ; Humans ; Cross-Sectional Studies ; Female ; Adult ; Male ; Health Knowledge, Attitudes, Practice ; Young Adult ; Child, Preschool ; Middle Aged ; Infant ; Patient Acceptance of Health Care/statistics & numerical data ; Patient Acceptance of Health Care/psychology ; Malaria/prevention & control ; Mothers/psychology ; Adolescent

Background: Vaccines have increasingly become some of the most effective public health tools for promoting health and reducing the burden of infectious diseases. The availability of a malaria vaccine for routine use will be a major milestone, nonetheless, trust by the public for the vaccine could pose a major challenge for its acceptance. Documented evidence such as the boycott of the oral polio vaccine in northern Nigeria and the failure of the Ebola vaccine trial in Ghana among others highlight the impact of public trust on vaccine acceptance.
Methods: This is an explorative cross-sectional mixed-method study conducted in the Kassena Nankana districts. The study was conducted in the Kassena Nankana Districts between May and December 2020. A total of 390 structured questionnaires were administrated to mothers and caregivers of children under five years of age while 15 in-depth interviews were conducted with mothers and health workers. STATA software Version 16.0 was used to interpret the quantitative data, where bivariate and multivariate regression analysis was performed to determine the influence of trust on vaccine acceptance while QSR NVivo 12 software was used to code the qualitative data to aid the thematic analysis.
Results: The results revealed that the level of knowledge of the RTS,S vaccine among participants was high. About 95.4% of the mothers had good knowledge of the malaria vaccine and more than half 61.2% of them got information about the vaccine from the health facility. The level of trust for the malaria vaccine was equally high with 91.4% of the mothers reporting that the vaccine treats childhood malaria. In a bivariate analysis, educational status (P = 0.013), ethnicity (P = 0.008), marital status (P = 0.041), education on the vaccine and perceived ineffectiveness P < 0.05, and trust for the malaria vaccine (P < 0.05) were found to be statistically associated with vaccine acceptance. Compared with participants who agree that vaccines are harmless to children, those who disagree were significantly less likely to accept vaccines (OR = 0.25, 95%CI [0.08, 0.83], p = 0.017). The qualitative data correspondingly revealed that mothers trusted vaccines which thus accounted for the high uptake of the malaria vaccine in the districts.
Conclusion: The results of this study suggest that trust in the malaria vaccine is critical for its uptake. Therefore, efforts towards improving acceptance of the vaccine should be focused on building and sustaining trust for the vaccine among mothers and community members.
Competing Interests: Declarations. Ethical approval: Ethical approval for the study was obtained from the Ghana Health Service Ethics Review Board (GHS-ERC032/02/20). Permission was obtained from the District Directors of Health Services at the Kassena-Nankana districts to access the contact list of the mothers from the health facilities. Oral informed consent was obtained before the interviews were conducted. The consent forms were translated into the preferred local language of the participants. All participants were informed before the start of the interview about project goals, how long the interview would last, their right to refuse being interviewed, the right to withdraw in the process of the interview and about the intended use of the results for scientific publications and also disseminate the findings to stakeholders. To ensure confidentiality, identification numbers were assigned to participants in the qualitative interviews instead of their names. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)

BMJ. 2008 Apr 5;336(7647):754-7. (PMID: 18309964)
Pediatrics. 2006 May;117(5):1532-41. (PMID: 16651306)
Matern Child Health J. 2011 Apr;15(3):386-94. (PMID: 20180003)
Nature. 2011 May 26;473(7348):446-7. (PMID: 21614056)
PLoS One. 2014 Oct 15;9(10):e109707. (PMID: 25334094)
Soc Sci Med. 2003 Apr;56(7):1453-68. (PMID: 12614697)
BMC Public Health. 2023 Nov 18;23(1):2283. (PMID: 37980467)
PLoS Med. 2007 Mar;4(3):e73. (PMID: 17388657)
Viral Immunol. 2018 Mar;31(2):184-194. (PMID: 29474132)
J Epidemiol Community Health. 2009 Dec;63(12):1010-5. (PMID: 19762455)
Children (Basel). 2016 Apr 29;3(2):. (PMID: 27417245)
Malar J. 2013 Feb 13;12:63. (PMID: 23405912)
Malar J. 2011 May 30;10:147. (PMID: 21624117)
Pan Afr Med J. 2014 Jul 21;18 Suppl 1:9. (PMID: 25328628)
Int J Epidemiol. 2012 Aug;41(4):968-76. (PMID: 22933645)
J Adolesc Health. 2016 Oct;59(4S):S40-S48. (PMID: 27664595)
J Pediatr. 2010 Apr;156(4):618-22. (PMID: 20056238)
Hum Vaccin Immunother. 2013 Aug;9(8):1774-8. (PMID: 23733039)

Keywords: Acceptance; Malaria; Trust; Vaccines

0 (Malaria Vaccines)

Date Created: 20241129 Date Completed: 20241130 Latest Revision: 20241202

20250114

PMC11606133

10.1186/s12936-024-05180-x

39614248