Structurally diverse coumarin derivatives from the buds of Edgeworthia gardneri and their cytotoxic activities.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : [Amsterdam] : Elsevier
      Original Publication: Milano : Inverni & Della Beffa S.p.A.
    • Subject Terms:
      Coumarins*/pharmacology ; Coumarins*/isolation & purification ; Coumarins*/chemistry ; Antineoplastic Agents, Phytogenic*/pharmacology ; Antineoplastic Agents, Phytogenic*/isolation & purification ; Phytochemicals*/pharmacology ; Phytochemicals*/isolation & purification; Humans ; Molecular Structure ; Structure-Activity Relationship ; Cell Line, Tumor ; China ; A549 Cells
    • Abstract:
      Five new coumarins, including three phenypropaninized coumarins edgegardnerols A-C (1-3), two bicoumarins edgegardnerols D and E (4 and 5), along with eight known analogues, were isolated and identified from the dried buds of E. gardneri. Their structures were elucidated by comprehensive analysis of their NMR, IR, UV, HR-ESI-MS, and ECD data. Furthermore, the absolute configurations of the glucose moiety were confirmed by HPLC analysis after acidic hydrolysis and chemical derivatization. The cytotoxic activities of all isolated compounds were evaluated against A549 and SMMC-7721 cell lines. Among the tested isolates, compound 12 showed the most potent cytotoxicity with IC 50 values of 22.65 μM and 25.83 μM in these two cell lines, respectively. Compared with cisplatin (29.78 μM), compound 12 exhibited stronger cytotoxic activity in A549 cell line. The preliminary structure-activity relationship showed that 7-hydroxy group on coumarin skeleton was structurally required for the cytotoxity against the A-549 and SMMC-7721 cell lines.
      Competing Interests: Declaration of competing interest The authors declare no competing financial interest.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Coumarin; Cytotoxic; Edgeworthia gardneri
    • Accession Number:
      0 (Coumarins)
      0 (Antineoplastic Agents, Phytogenic)
      0 (Phytochemicals)
    • Publication Date:
      Date Created: 20241128 Date Completed: 20241230 Latest Revision: 20241230
    • Publication Date:
      20241231
    • Accession Number:
      10.1016/j.fitote.2024.106314
    • Accession Number:
      39608467