The Impact of the Dietary Inflammatory Index, Fasting Blood Glucose, and Smoking Status on the Incidence and Survival of Pancreatic Cancer: A Retrospective Case-Control Study and a Prospective Study.

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  • Additional Information
    • Source:
      Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI Publishing
    • Subject Terms:
      Pancreatic Neoplasms*/mortality ; Pancreatic Neoplasms*/blood ; Pancreatic Neoplasms*/epidemiology ; Blood Glucose*/metabolism ; Blood Glucose*/analysis ; Smoking*/adverse effects ; Smoking*/epidemiology ; Fasting*/blood ; Inflammation*/blood ; Diet*/adverse effects; Humans ; Male ; Female ; Middle Aged ; Case-Control Studies ; Prospective Studies ; Incidence ; Retrospective Studies ; Aged ; Risk Factors ; Republic of Korea/epidemiology ; Proportional Hazards Models
    • Abstract:
      Background: Pancreatic cancer (PC), a highly malignant cancer with a poor diagnosis, may be influenced by diet-related inflammation. This study examined the association between dietary inflammatory index (DII) scores and the incidence and prognosis of PC in Korea.
      Methods: A total of 55 patients with PC were matched with 280 healthy controls (HCs) by age and sex. We also analyzed the combined effects of DII scores and fasting blood glucose (FBG) levels or smoking status on the risk of PC and performed a survival analysis using the Cox proportional hazards method.
      Results: The DII scores were higher in the patients with PC than those in HCs (odds ratio [OR] = 3.36, confidence interval [CI] = 1.16-9.73, p = 0.03), and the effect was larger in women (OR = 6.13, CI = 1.11-33.82, p = 0.04). A high DII score was jointly associated with FBG ≥ 126 mg/dL in raising PC risk [OR = 32.5, relative excess risk due to interaction/synergy (RERI/S) index = 24.2/4.34, p -interaction = 0.04], indicating a multiplicative interaction. A high DII score combined with ex/current smoker status increased PC risk through an additive interaction (RERI/S = 1.01/1.54, p -interaction = 0.76). However, DII scores did not influence disease-free survival.
      Conclusions: The consumption of an anti-inflammatory diet, coupled with maintaining normal FBG levels and abstaining from smoking, may help reduce the risk of PC by mitigating pancreatic inflammation.
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    • Grant Information:
      2411890-1, 2024 Republic of Korea National Cancer Center
    • Contributed Indexing:
      Keywords: dietary inflammatory index; fasting blood glucose; pancreatic cancer; smoking
    • Accession Number:
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20241127 Date Completed: 20241127 Latest Revision: 20241130
    • Publication Date:
      20241202
    • Accession Number:
      PMC11597200
    • Accession Number:
      10.3390/nu16223941
    • Accession Number:
      39599726