Exploring the Effect of Resveratrol, Tyrosol, and Their Derivatives on Platelet-Activating Factor Biosynthesis in U937 Cells.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, c1995-

Resveratrol*/pharmacology ; Platelet Activating Factor*/metabolism ; Platelet Activating Factor*/biosynthesis ; Phenylethyl Alcohol*/analogs & derivatives ; Phenylethyl Alcohol*/pharmacology; Humans ; U937 Cells ; Interleukin-1beta/metabolism ; Acetyltransferases/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism

Platelet-activating factor (PAF) is a potent lipid mediator, involved in thrombosis, inflammation, and atherosclerosis. The protective effect of wine and olive oil against atherosclerotic diseases is largely attributed to their phenolic compounds and mostly to resveratrol and tyrosol. Both compounds have been reported to inhibit PAF biosynthesis in interleukin-1β (IL-1β)-stimulated monocytes and also to attenuate PAF biosynthesis in cell lysates. The aim of this study was to investigate the effects of resveratrol, tyrosol, and their derivatives on unstimulated U937 cells and to explore the intracellular messaging pathways that participate in the activation of PAF biosynthesis in the same cell line. Tyrosol and its derivatives did not exert any substantial effect on PAF biosynthesis. Resveratrol (50 and 100 μM), as well as its methoxy derivative (5-20 μM), caused a reduction in the PAF biosynthetic enzymes' activity by 20-43% after 24 h of incubation. On the other hand, lower resveratrol concentration (10 μM) and higher concentration of the methoxy derivative (50 μM) increased the Ca ²⁺ -dependent lyso-PAF acetyltransferase (LysoPAF-ATC) activity by 28-45% after half-hour incubation via p38 mitogen-activated protein kinase (p38-MAPK) action. IL-1β activated PAF biosynthetic pathways via different signaling pathways, with phospholipase C-β (PLC-β) being a key enzyme.

Crit Rev Clin Lab Sci. 2007;44(5-6):483-525. (PMID: 17943494)
Food Funct. 2019 Feb 20;10(2):514-528. (PMID: 30746536)
J Biol Chem. 1987 Feb 25;262(6):2520-7. (PMID: 3029085)
Mol Nutr Food Res. 2016 Sep;60(9):1924-32. (PMID: 26990242)
J Cell Commun Signal. 2007 Sep;1(2):103-11. (PMID: 18481201)
Molecules. 2022 Jan 10;27(2):. (PMID: 35056739)
Nutr Metab Cardiovasc Dis. 2014 Jun;24(6):639-47. (PMID: 24552647)
J Pharmacol Exp Ther. 2006 Jun;317(3):980-8. (PMID: 16525036)
Biochim Biophys Acta. 2015 Jun;1852(6):1155-77. (PMID: 25451966)
FEBS Lett. 1999 May 14;451(1):63-7. (PMID: 10356984)
J Nutr Biochem. 2002 Nov;13(11):636-644. (PMID: 12550060)
Sci Signal. 2010 Jan 19;3(105):cm1. (PMID: 20086235)
Can J Biochem Physiol. 1959 Aug;37(8):911-7. (PMID: 13671378)
Cardiovasc Ther. 2017 Feb;35(1):64-70. (PMID: 27790832)
Biochim Biophys Acta. 1997 Sep 4;1348(1-2):111-6. (PMID: 9370322)
Nutrients. 2019 Mar 22;11(3):. (PMID: 30909449)
J Biol Chem. 2014 May 30;289(22):15566-76. (PMID: 24742674)
Food Chem Toxicol. 2013 Dec;62:172-8. (PMID: 23994089)
J Biol Chem. 2004 Jan 30;279(5):3497-508. (PMID: 14617636)
Arch Biochem Biophys. 2018 Aug 15;652:18-26. (PMID: 29885291)
Food Sci Nutr. 2020 Aug 13;8(9):4639-4655. (PMID: 32994927)
Front Pharmacol. 2022 Feb 14;13:806470. (PMID: 35237163)
Mol Nutr Food Res. 2017 Dec;61(12):. (PMID: 28815947)
J Biol Chem. 2010 Sep 24;285(39):29857-62. (PMID: 20663880)
Anal Biochem. 1976 May 7;72:248-54. (PMID: 942051)
Biomolecules. 2023 Apr 20;13(4):. (PMID: 37189447)
Nutrients. 2018 Nov 12;10(11):. (PMID: 30424533)
Nutr Metab Cardiovasc Dis. 2006 Jul;16(5):322-9. (PMID: 16829340)
Crit Rev Food Sci Nutr. 2018 Jun 13;58(9):1428-1447. (PMID: 28001084)
Biofactors. 2022 Nov;48(6):1217-1225. (PMID: 36176024)
J Lipid Res. 2014 Jul;55(7):1386-96. (PMID: 24850807)
Nutr Metab (Lond). 2024 May 16;21(1):26. (PMID: 38755627)
Exp Mol Med. 2007 Aug 31;39(4):421-38. (PMID: 17934330)
Food Chem. 2014 Dec 15;165:50-9. (PMID: 25038648)
Nutrients. 2019 Apr 26;11(5):. (PMID: 31035454)
Neurosci Lett. 1999 Apr 2;264(1-3):141-4. (PMID: 10320034)
Fitoterapia. 2017 Nov;123:51-58. (PMID: 28964873)
J Immunol Methods. 1983 Dec 16;65(1-2):55-63. (PMID: 6606682)
Cytokine. 2013 Aug;63(2):97-104. (PMID: 23673285)
J Biol Chem. 1999 Feb 26;274(9):5469-73. (PMID: 10026159)
J Agric Food Chem. 2002 Feb 27;50(5):1150-60. (PMID: 11853496)
Clin Biochem. 2018 Sep;60:1-10. (PMID: 30142319)
Biochim Biophys Acta. 2015 Jun;1852(6):1114-23. (PMID: 25315298)
J Vet Med Sci. 2016 Oct 1;78(9):1429-1438. (PMID: 27238160)
Food Funct. 2012 Feb;3(2):110-9. (PMID: 22134555)
Biochemistry. 2013 Aug 6;52(31):5164-6. (PMID: 23848362)
Phytother Res. 2019 Sep;33(9):2221-2243. (PMID: 31359516)
Pharmaceutics. 2024 Apr 22;16(4):. (PMID: 38675230)
Nutrients. 2018 Nov 21;10(11):. (PMID: 30469326)
Biochim Biophys Acta. 1990 Jan 23;1051(1):100-7. (PMID: 2153414)
Biochem Biophys Res Commun. 2018 Jan 1;495(1):1195-1200. (PMID: 29183727)
J Agric Food Chem. 2002 Apr 24;50(9):2684-94. (PMID: 11958642)
Expert Opin Investig Drugs. 2012 Aug;21(8):1155-67. (PMID: 22694351)
Biochem Pharmacol. 2006 May 14;71(10):1479-87. (PMID: 16580641)
Drug Res (Stuttg). 2022 Jan;72(1):5-17. (PMID: 34412126)
BMC Complement Altern Med. 2017 Jun 13;17(1):309. (PMID: 28610607)
Br J Nutr. 2019 May;121(9):982-991. (PMID: 30940217)
J Biol Chem. 2007 Mar 2;282(9):6532-9. (PMID: 17182612)
Biochim Biophys Acta. 2002 Oct 21;1592(2):175-84. (PMID: 12379481)
J Nutr Biochem. 2013 May;24(5):819-23. (PMID: 22925919)
Cell Physiol Biochem. 2017;43(3):1025-1036. (PMID: 28968596)
Int J Mol Sci. 2017 Oct 25;18(11):. (PMID: 29068387)
Int J Cancer. 1976 May 15;17(5):565-77. (PMID: 178611)
Molecules. 2019 Dec 03;24(23):. (PMID: 31816871)
Free Radic Biol Med. 2019 Jan;130:8-22. (PMID: 30366059)
Molecules. 2019 May 24;24(10):. (PMID: 31137753)
Biofactors. 2022 Nov;48(6):1189-1202. (PMID: 36029481)
Biomolecules. 2021 May 28;11(6):. (PMID: 34071485)
Biofactors. 2022 Nov;48(6):1203-1216. (PMID: 36370412)
Anat Cell Biol. 2011 Sep;44(3):194-203. (PMID: 22025971)
Biochem Pharmacol. 2006 Nov 30;72(11):1439-52. (PMID: 16920072)
Prostaglandins Other Lipid Mediat. 2017 May;130:23-29. (PMID: 28323197)
Blood. 2011 Apr 7;117(14):3720-32. (PMID: 21304099)
Antioxidants (Basel). 2023 May 23;12(6):. (PMID: 37371870)
J Biol Chem. 2002 Apr 26;277(17):14884-93. (PMID: 11842088)
Adv Pharm Bull. 2023 Jan;13(1):36-47. (PMID: 36721803)
Molecules. 2023 Jul 20;28(14):. (PMID: 37513418)
J Agric Food Chem. 2007 Jan 10;55(1):80-9. (PMID: 17199317)
Food Chem Toxicol. 2019 Mar;125:520-527. (PMID: 30735752)
J Biol Chem. 2008 Apr 25;283(17):11097-106. (PMID: 18285344)
Int J Mol Sci. 2022 Jul 04;23(13):. (PMID: 35806429)
Food Chem Toxicol. 2017 Nov;109(Pt 1):526-533. (PMID: 28974441)
Neurochem Res. 2000 May;25(5):705-13. (PMID: 10905633)
Int J Oncol. 2008 Jul;33(1):81-92. (PMID: 18575753)
Food Funct. 2017 Aug 1;8(8):2905-2914. (PMID: 28740975)
Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt B):176-83. (PMID: 26358846)
Cell Physiol Biochem. 2018;50(3):911-923. (PMID: 30355929)
Int J Biochem Cell Biol. 2013 Dec;45(12):2821-31. (PMID: 24128857)
Am J Med. 2002 Dec 30;113 Suppl 9B:71S-88S. (PMID: 12566142)

Keywords: acetyltransferase; cholinephosphotransferase; extracellular signal-regulated kinase; inflammation; inhibitors; interleukin-1β; messaging pathways; mitogen-activated protein kinase; phenolic compounds; phospholipase C-β

1AK4MU3SNX (4-hydroxyphenylethanol)
Q369O8926L (Resveratrol)
0 (Platelet Activating Factor)
ML9LGA7468 (Phenylethyl Alcohol)
0 (Interleukin-1beta)
EC 2.3.1.- (Acetyltransferases)
EC 2.3.1.67 (1-alkylglycerophosphocholine acetyltransferase)
EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)

Date Created: 20241127 Date Completed: 20241127 Latest Revision: 20241130

20241202

PMC11597468

10.3390/molecules29225419

39598808