Analysis of independent risk factors for hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with cirrhosis combined with diabetes.

Publisher: Lippincott Williams And Wilkins Country of Publication: England NLM ID: 9000874 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5687 (Electronic) Linking ISSN: 0954691X NLM ISO Abbreviation: Eur J Gastroenterol Hepatol Subsets: MEDLINE

Publication: London : Lippincott Williams And Wilkins
Original Publication: [London, UK ; Philadelphia, PA, USA] : Current Science, c1989-

Portasystemic Shunt, Transjugular Intrahepatic*/adverse effects ; Hepatic Encephalopathy*/etiology ; Liver Cirrhosis*/complications ; Ascites*/etiology; Humans ; Female ; Male ; Risk Factors ; Middle Aged ; Retrospective Studies ; Aged ; Age Factors ; Adult ; Diabetes Mellitus/epidemiology ; Logistic Models ; Kaplan-Meier Estimate ; Diabetes Complications ; ROC Curve ; Treatment Outcome ; Postoperative Complications/etiology

Objective: This study aimed to reveal the independent risk factors for overt hepatic encephalopathy (OHE) after transjugular intrahepatic portosystemic shunt (TIPS) in patients with decompensated cirrhosis complicated with diabetes.
Patients and Methods: This study retrospectively analyzed 126 consecutive patients with cirrhosis combined with diabetes who underwent TIPS in our department from January 2016 to June 2022. The patients were divided into two groups according to the presence or absence of OHE after TIPS. Data were analyzed using the χ 2 -tests, unpaired t -tests, logistic regression, receiver operating characteristic curves, and Kaplan-Meier curves.
Results: Age and ascites were independent risk factors for OHE after TIPS in patients with cirrhosis and diabetes. Elder patients had a higher risk of postoperative OHE than younger patients [odds ratio (OR): 1.040; 95% confidence interval (CI): 1.003-1.079]. Compared with patients without ascites, patients with ascites were significantly more likely to develop OHE (OR: 3.757; 95% CI: 1.274-11.080; OR: 4.338; 95% CI: 1.069-17.603).
Conclusion: Age and ascites are independent risk factors of post-TIPS OHE in cirrhotic patients with diabetes.
(Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)

Am J Gastroenterol. 2008 Nov;103(11):2738-46. (PMID: 18775022)
Nat Rev Dis Primers. 2022 Jun 23;8(1):43. (PMID: 35739133)
Hepatology. 1994 Jul;20(1 Pt 1):119-25. (PMID: 8020880)
Hepatology. 2017 Jan;65(1):310-335. (PMID: 27786365)
Hepatology. 2010 May;51(5):1675-82. (PMID: 20186844)
Hepatology. 2003 Jul;38(1):258-66. (PMID: 12830009)
Eur J Gastroenterol Hepatol. 2019 Oct;31(10):1264-1269. (PMID: 31136318)
Saudi J Gastroenterol. 2010 Jul-Sep;16(3):181-7. (PMID: 20616413)
Gastroenterology. 2010 Oct;139(4):1246-56, 1256.e1-5. (PMID: 20558165)
Aliment Pharmacol Ther. 2020 Aug;52(3):527-536. (PMID: 32598080)
Hepatol Int. 2019 Jan;13(1):1-21. (PMID: 30656520)
J Hepatol. 2001 Jan;34(1):46-52. (PMID: 11211907)
Gastroenterol Res Pract. 2013;2013:398172. (PMID: 23606833)
J Clin Exp Hepatol. 2018 Jun;8(2):156-161. (PMID: 29892178)
JAMA Intern Med. 2014 Feb 1;174(2):251-8. (PMID: 24322595)
J Gastrointestin Liver Dis. 2015 Sep;24(3):301-7. (PMID: 26405702)
Diabet Med. 1998 Jul;15(7):539-53. (PMID: 9686693)
Gut. 2020 Jul;69(7):1173-1192. (PMID: 32114503)
Dig Dis Sci. 2015 Apr;60(4):1059-66. (PMID: 25316553)
J Hepatol. 2015 Nov;63(5):1133-8. (PMID: 26206073)

Date Created: 20241126 Date Completed: 20241221 Latest Revision: 20250104

20250104

PMC11658019

10.1097/MEG.0000000000002889

39589821