In-situ oxidative polymerization of dopamine triggered by CuO 2 in acidic condition and application in "turn-off" sensing.

Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7808782 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-5073 (Electronic) Linking ISSN: 00263672 NLM ISO Abbreviation: Mikrochim Acta Subsets: MEDLINE

Original Publication: Wien ; New York : Springer-Verlag.

Copper*/chemistry ; Dopamine*/blood ; Dopamine*/chemistry ; Polymerization* ; Oxidation-Reduction* ; Limit of Detection* ; Indoles*/chemistry; Humans ; Hydrogen-Ion Concentration ; Polymers/chemistry ; Fluorescence Resonance Energy Transfer/methods ; Hydroxyl Radical/chemistry ; Hydroxyl Radical/analysis

Dopamine (DA) is a key neurotransmitter whose concentration affects various neurological disorders. Unlike previous methods that synthesize non-fluorescent polydopamine (NFL-PDA) under alkaline conditions, this study introduces a novel "turn-off" sensing method for DA using NFL-PDA synthesized through a unique reaction pathway. In our approach, CuO 2 nanodots, created via a simple reduction method, catalyze the formation of hydroxyl radicals (•OH) in acidic conditions, triggering the oxidative polymerization of DA into NFL-PDA. The reaction between DA and CuO 2 nanodots in acidic solution was examined to understand the process. UiO-66-NH 2 was then used to test NFL-PDA's fluorescence quenching ability and to further investigate the DA determination mechanism. Results showed that fluorescence quenching was due to enhanced non-radiative energy transfer and Förster resonance energy transfer (FRET) between NFL-PDA and UiO-66-NH 2 . This led to the development of a simple "turn-off" fluorometric DA determination method with a linear range of 0.1-200 μmol/L and a limit of detection (LOD) of 0.0575 μmol/L. Although this method does not outperform existing NFL-PDA synthesis methods under alkaline conditions, it provides a new synthesis approach and application for sensing DA, contributing to the basic theory of chemical sensing. Additionally, DA determination in human serum samples was successfully achieved, with results consistent with high-performance liquid chromatography (HPLC).
Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)

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2022YFC2106200 National Key Research and Development Program of China; 2022YFC2106200 National Key Research and Development Program of China; 81271930 National Natural Science Foundation of China

Keywords: CuO2; Dopamine; NFL-PDA; Turn-off fluorescence; UiO-66-NH2

789U1901C5 (Copper)
VTD58H1Z2X (Dopamine)
V1XJQ704R4 (cupric oxide)
0 (Indoles)
0 (Polymers)
0 (polydopamine)
3352-57-6 (Hydroxyl Radical)

Date Created: 20241125 Date Completed: 20241125 Latest Revision: 20241219

20241219

10.1007/s00604-024-06791-6

39586875