Neural integration of egocentric and allocentric visual cues in the gaze system.

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  • Additional Information
    • Publication Information:
      Ahead of Print
    • Source:
      Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE
    • Publication Information:
      Publication: Bethesda Md : American Physiological Society
      Original Publication: Washington [etc.]
    • Abstract:
      A fundamental question in neuroscience is how the brain integrates egocentric (body-centered) and allocentric (landmark-centered) visual cues, but for many years this question was ignored in sensorimotor studies. This changed in recent behavioral experiments, but the underlying physiology of ego / allocentric integration remained largely unstudied. The specific goal of this review is to explain how prefrontal neurons integrate eye-centered and landmark-centred visual codes for optimal gaze behavior. First, we briefly review the whole-brain / behavioral mechanisms for ego / allocentric integration in the human and summarize egocentric coding mechanisms in the primate gaze system. We then focus in more depth on cellular mechanisms for ego / allocentric coding in the frontal and supplementary eye fields. We first explain how prefrontal visual responses integrate eye-centered target and landmark codes to produce a transformation toward landmark-centered coordinates. Next, we describe what happens when a landmark shifts during the delay between seeing and acquiring a remembered target, initially resulting in independently co-existing ego / allocentric memory codes. We then describe how these codes are re-integrated in the motor burst for the gaze shift. Deep network simulations suggest that these properties emerge spontaneously for optimal gaze behavior. Finally, we synthesize these observations and relate them to normal brain function through a simplified conceptual model. Together, these results show that integration of visuospatial features continues well beyond visual cortex and suggests a general cellular mechanism for goal-directed visual behaviour.
    • Grant Information:
      of Canada Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC); Canada First Research Excellence Fund; Vision: Science to Applications (VISTA) program; Research Chair York University; Canadian Government | Canadian Institutes of Health Research (CIHR)
    • Contributed Indexing:
      Keywords: Allocentric; Egocentric; Eye movements; Frontal Cortex; Gaze system
    • Publication Date:
      Date Created: 20241125 Latest Revision: 20241125
    • Publication Date:
      20241126
    • Accession Number:
      10.1152/jn.00498.2024
    • Accession Number:
      39584726