Non-invasive brain stimulation enhances motor and cognitive performances during dual tasks in patients with Parkinson's disease: a systematic review and meta-analysis.

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  • Author(s): Lee H;Lee H; Choi BJ; Choi BJ; Kang N; Kang N; Kang N; Kang N
  • Source:
    Journal of neuroengineering and rehabilitation [J Neuroeng Rehabil] 2024 Nov 25; Vol. 21 (1), pp. 205. Date of Electronic Publication: 2024 Nov 25.
  • Publication Type:
    Journal Article; Systematic Review; Meta-Analysis; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101232233 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-0003 (Electronic) Linking ISSN: 17430003 NLM ISO Abbreviation: J Neuroeng Rehabil Subsets: MEDLINE
    • Publication Information:
      Original Publication: [London] : BioMed Central, 2004-
    • Subject Terms:
      Parkinson Disease*/rehabilitation ; Parkinson Disease*/therapy ; Parkinson Disease*/psychology ; Parkinson Disease*/physiopathology ; Cognition*/physiology; Humans ; Psychomotor Performance/physiology ; Transcranial Direct Current Stimulation/methods ; Transcranial Magnetic Stimulation/methods
    • Abstract:
      Background: Parkinson's disease (PD) induces progressive deficits in motor and cognitive functions as well as impaired dual-task performance requiring both motor and cognitive functions. This systematic review and meta-analysis evaluated the effects of non-invasive brain stimulation (NIBS) on dual-task performance in patients with PD.
      Methods: 11 studies met the following inclusion criteria: (a) patients with PD, (b) NIBS intervention, (c) comparison with the sham stimulation group, (d) motor and cognitive performance outcomes during dual tasks, and (e) randomized controlled trials with parallel or crossover designs. Individual effect size (i.e., comparison) was quantified by comparing motor and cognitive performances changes during dual tasks between active NIBS and sham stimulation conditions. Thus, higher values of the overall effect size indicate more improvements in either motor or cognitive performances after NIBS. Moreover, moderator variable analyses determined whether NIBS effects on dual-task performances differed depending on targeted brain regions. Finally, meta-regression analyses determined whether NIBS effects on dual-task performances were associated with demographic characteristics.
      Results: The random-effects model meta-analysis revealed that NIBS significantly improved motor (73 comparisons from 11 studies) and cognitive (12 comparisons from four studies) performances during dual tasks in patients with PD. Specifically, anodal transcranial direct current stimulation protocols on the dorsolateral prefrontal cortex were effective. Moreover, greater improvements in motor performance during dual tasks significantly correlated with decreased age and increased proportion of females, respectively.
      Conclusion: This meta-analysis suggests that excitatory stimulation on the dorsolateral prefrontal cortex may be effective for improving dual-task performance in patients with PD.
      Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
      (© 2024. The Author(s).)
    • References:
      Ann Neurol. 2021 Sep;90(3):428-439. (PMID: 34216034)
      Aging Clin Exp Res. 2018 Sep;30(9):1137-1142. (PMID: 29198058)
      Neuroimage. 2017 May 15;152:207-220. (PMID: 28263926)
      J Neurosci. 2011 Jul 13;31(28):10340-6. (PMID: 21753011)
      Schizophr Res. 2011 Sep;131(1-3):264-5. (PMID: 21669513)
      J Parkinsons Dis. 2022;12(1):421-436. (PMID: 34744052)
      Maturitas. 2018 Jul;113:53-72. (PMID: 29903649)
      Front Hum Neurosci. 2020 Nov 20;14:592532. (PMID: 33328938)
      Mech Ageing Dev. 2001 Jan;122(1):1-29. (PMID: 11163621)
      J Clin Neurosci. 2022 Jun;100:184-191. (PMID: 35487026)
      J Neuroeng Rehabil. 2019 Jul 17;16(1):90. (PMID: 31315679)
      Stat Med. 2002 Jun 15;21(11):1539-58. (PMID: 12111919)
      Clin Neurophysiol. 2010 Mar;121(3):441-7. (PMID: 20071228)
      J Psychiatr Res. 1975 Nov;12(3):189-98. (PMID: 1202204)
      Neurology. 2005 Oct 25;65(8):1239-45. (PMID: 16247051)
      Front Aging Neurosci. 2019 Jun 18;11:144. (PMID: 31275139)
      Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12566-71. (PMID: 16107540)
      Gait Posture. 2021 Feb;84:11-16. (PMID: 33260076)
      Emerg Med J. 2020 Jun;37(6):387. (PMID: 32253195)
      Neurology. 2010 Jul 13;75(2):116-24. (PMID: 20574039)
      PLoS One. 2016 Jun 30;11(6):e0158497. (PMID: 27359338)
      Exp Brain Res. 2021 Jul;239(7):2077-2087. (PMID: 33914138)
      Parkinsons Dis. 2012;2012:918719. (PMID: 22135764)
      Neurology. 1967 May;17(5):427-42. (PMID: 6067254)
      Gait Posture. 2017 Jul;56:76-81. (PMID: 28521148)
      Neuropsychopharmacology. 2010 Jan;35(1):70-85. (PMID: 19657332)
      Neuropsychologia. 2003;41(6):645-54. (PMID: 12591022)
      Clin Neurophysiol. 2007 May;118(5):1028-32. (PMID: 17368094)
      Mov Disord. 2007 May 15;22(7):1046-50. (PMID: 17575584)
      Brain Topogr. 2017 Sep;30(5):656-672. (PMID: 28213645)
      Front Hum Neurosci. 2019 Jun 13;13:190. (PMID: 31263404)
      Mov Disord. 2018 Dec;33(12):1972-1973. (PMID: 30423199)
      BMJ. 2021 Mar 29;372:n71. (PMID: 33782057)
      Ageing Res Rev. 2021 Sep;70:101377. (PMID: 34089900)
      Ann Neurol. 2020 Nov;88(5):933-945. (PMID: 32827221)
      Brain Stimul. 2020 May - Jun;13(3):530-532. (PMID: 32289670)
      Age Ageing. 2006 Nov;35(6):619-24. (PMID: 17047008)
      Neurosci Biobehav Rev. 2011 Jan;35(3):715-28. (PMID: 20833198)
      Lancet Neurol. 2019 Jul;18(7):697-708. (PMID: 30975519)
      Neurology. 2023 Mar 28;100(13):e1386-e1394. (PMID: 36581466)
      Front Aging Neurosci. 2011 Apr 09;3:5. (PMID: 21519394)
      Nat Rev Neurosci. 2017 Jul;18(7):435-450. (PMID: 28592904)
      Radiology. 2012 Apr;263(1):226-34. (PMID: 22371611)
      J Neurol. 2023 Jul;270(7):3442-3450. (PMID: 36952012)
      Eur J Neurosci. 2009 Jun;29(11):2187-96. (PMID: 19490021)
      Cogn Psychol. 2000 Aug;41(1):49-100. (PMID: 10945922)
      Neuropsychology. 2017 Sep;31(6):613-623. (PMID: 28414497)
      Clin Neurophysiol. 2020 Feb;131(2):474-528. (PMID: 31901449)
      Cereb Cortex. 2015 Oct;25(10):3330-42. (PMID: 24925772)
      Nat Rev Dis Primers. 2017 Mar 23;3:17013. (PMID: 28332488)
      Clin Neurophysiol. 2017 Nov;128(11):2318-2329. (PMID: 29040922)
      Front Neural Circuits. 2022 May 20;16:867053. (PMID: 35669454)
      Ann Neurol. 1990 Oct;28(4):547-55. (PMID: 2132742)
      Transl Neurodegener. 2016 Oct 28;5:18. (PMID: 27800157)
      Exp Brain Res. 2015 May;233(5):1575-83. (PMID: 25724513)
      Mov Disord. 2021 Jan;36(1):106-117. (PMID: 33002231)
      Res Synth Methods. 2010 Apr;1(2):97-111. (PMID: 26061376)
      Clin Neurol Neurosurg. 2023 Mar;226:107604. (PMID: 36739707)
      Mov Disord. 2008 Nov 15;23(15):2129-70. (PMID: 19025984)
      J Educ Eval Health Prof. 2023;20:24. (PMID: 37619974)
      Gait Posture. 2020 May;78:1-5. (PMID: 32146157)
      Front Aging Neurosci. 2022 Feb 07;14:807151. (PMID: 35197844)
      J Physiol. 2003 Nov 15;553(Pt 1):293-301. (PMID: 12949224)
      Cochrane Database Syst Rev. 2019 Oct 3;10:ED000142. (PMID: 31643080)
      BMJ. 1997 Sep 13;315(7109):629-34. (PMID: 9310563)
      J Neurosci. 2001 Aug 1;21(15):RC157. (PMID: 11459878)
      Int J Psychophysiol. 2020 May;151:70-79. (PMID: 32109499)
      J Am Geriatr Soc. 2005 Apr;53(4):695-9. (PMID: 15817019)
      Front Hum Neurosci. 2015 May 05;9:246. (PMID: 25999838)
      Arch Ital Biol. 2014 Dec;152(4):247-58. (PMID: 25987184)
      Front Neurol. 2020 Dec 10;11:601686. (PMID: 33362703)
      Neurosci Lett. 2016 Jul 28;626:1-5. (PMID: 27181509)
      Acta Neurol Scand. 2011 Jan;123(1):20-7. (PMID: 20199514)
      Neurobiol Dis. 2015 Oct;82:226-234. (PMID: 26102020)
      Parkinsonism Relat Disord. 2021 Jul;88:28-33. (PMID: 34102418)
      Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jan 4;64:325-33. (PMID: 25747801)
      Brain Res Bull. 2018 Sep;142:78-87. (PMID: 29958911)
      Front Neurosci. 2020 Mar 10;14:157. (PMID: 32210745)
      Cereb Cortex. 2018 Jul 1;28(7):2636-2646. (PMID: 29688276)
      Transl Psychiatry. 2019 Mar 15;9(1):115. (PMID: 30877269)
      Brain Stimul. 2016 Jan-Feb;9(1):1-7. (PMID: 26350410)
      Front Neurol. 2022 Oct 14;13:974985. (PMID: 36313494)
      Neurochem Res. 2019 Jan;44(1):38-48. (PMID: 30209673)
      Mov Disord. 2014 Jul;29(8):1064-9. (PMID: 24789677)
      Behav Brain Res. 2015;287:27-33. (PMID: 25804362)
      Brain Stimul. 2021 Jan-Feb;14(1):154-160. (PMID: 33359603)
      Endocrine. 2003 Jun;21(1):77-9. (PMID: 12777706)
      Brain Stimul. 2020 Nov - Dec;13(6):1588-1599. (PMID: 32949779)
      Brain Sci. 2022 Jul 15;12(7):. (PMID: 35884734)
      Parkinsonism Relat Disord. 2016 Apr;25:91-6. (PMID: 26861167)
      eNeurologicalSci. 2022 Sep 01;29:100422. (PMID: 36097517)
      Neuroimage. 2007 Oct 1;37(4):1338-45. (PMID: 17683949)
      Psychol Res. 2014 Nov;78(6):836-51. (PMID: 24668506)
      Int J Epidemiol. 2011 Dec;40(6):1732-4. (PMID: 20026595)
      Mov Disord. 2006 Sep;21(9):1343-9. (PMID: 16721732)
      J Exp Psychol Hum Percept Perform. 2003 Feb;29(1):3-18. (PMID: 12669744)
      Front Neurosci. 2023 Apr 11;17:1157920. (PMID: 37113144)
      Curr Opin Neurol. 2010 Aug;23(4):407-12. (PMID: 20610991)
      Neuropsychopharmacology. 2004 Aug;29(8):1573-8. (PMID: 15199378)
      Neurobiol Aging. 2020 Nov;95:240-249. (PMID: 32866885)
      BMJ. 2003 Sep 6;327(7414):557-60. (PMID: 12958120)
      Brain Cogn. 2017 Jul;115:41-46. (PMID: 28433922)
    • Contributed Indexing:
      Keywords: Dorsolateral prefrontal cortex; Dual task; Non-invasive brain stimulation; Parkinson’s disease; Transcranial direct current stimulation
    • Publication Date:
      Date Created: 20241124 Date Completed: 20241124 Latest Revision: 20241127
    • Publication Date:
      20241202
    • Accession Number:
      PMC11587594
    • Accession Number:
      10.1186/s12984-024-01505-8
    • Accession Number:
      39581969