Sex and estradiol effects in the rodent dorsal striatum.

Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-9568 (Electronic) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE

Publication: : Oxford : Wiley-Blackwell
Original Publication: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press, c1989-

Estradiol*/pharmacology ; Estradiol*/metabolism; Animals ; Corpus Striatum/metabolism ; Corpus Striatum/drug effects ; Corpus Striatum/physiology ; Sex Characteristics ; Female ; Receptors, Estrogen/metabolism ; Male ; Dopamine/metabolism ; Rodentia ; Learning/physiology ; Learning/drug effects

17β-Estradiol (E2) is a sex hormone that acts on many brain regions to produce changes in neuronal activity and learning. A key brain region sensitive to E2 is the dorsal striatum (also called caudate-putamen), which controls motor behaviour, goal-directed learning and habit learning. In adult rodents, oestrogen receptors (ERs) in the dorsal striatum are localized to the plasma membrane and include ERα, ERβ and G protein-coupled ER (GPER). E2, either naturally produced or exogenously applied, may influence neuronal excitability, basal synaptic transmission and long-term synaptic potentiation. These effects may be due to direct action on signalling pathways or may be due to changes in dopamine availability. In particular, estradiol influences dopamine release, dopamine receptor expression and dopamine transporter expression. We review the cellular effects that E2 has in the dorsal striatum, distinguishing between exogenously applied E2 and the oestrous cycle, as well as its influence on dorsal striatal-dependent motor and learning behaviour.
(© 2024 The Author(s). European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)

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R01 DA056113 United States DA NIDA NIH HHS; P50 HD103556 United States HD NICHD NIH HHS; George Mason University; R01 MH 087463 United States MH NIMH NIH HHS; R01 056113 National Institute of Drug Abuse; R01 MH 087463 United States MH NIMH NIH HHS; P50 HD103556 United States HD NICHD NIH HHS

Keywords: dopamine; oestrogen receptors; oestrus; sex differences; synaptic plasticity

4TI98Z838E (Estradiol)
0 (Receptors, Estrogen)
VTD58H1Z2X (Dopamine)

Date Created: 20241122 Date Completed: 20241216 Latest Revision: 20241216

20241216

10.1111/ejn.16607

39573926