Prevalence and associated risk factors of Brucella abortus and Brucella melitensis in humans and cattle populations: A comprehensive study.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 7808924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1667 (Electronic) Linking ISSN: 01479571 NLM ISO Abbreviation: Comp Immunol Microbiol Infect Dis Subsets: MEDLINE
    • Publication Information:
      Publication: Exeter : Elsevier Science Ltd
      Original Publication: Oxford, Elmsford, N. Y., Pergamon Press.
    • Subject Terms:
    • Abstract:
      A zoonotic disease unique to South Asia, brucellosis causes major public health and financial problems, notably in Pakistan. This research aimed to ascertain the molecular frequency of Brucella abortus and Brucella melitensis in humans and cattle and to pinpoint related risk factors in the Southern Khyber Pakhtunkhwa, Pakistan, districts. A total of 800 blood samples, 600 from cattle and 200 from humans, were gathered and examined using traditional PCR targeting the IS711 locus. In humans, the molecular frequency of Brucella melitensis and Brucella abortus was 16.5 %; in cattle, it was 9.1 %. Risk factor analysis in cattle revealed that seasonality, geographic location, sex, and insemination method significantly impacted brucellosis prevalence· Higher risk was observed in female cattle, those naturally inseminated, and during the summer months, particularly in regions such as Bannu· In humans, univariate logistic regression identified potential risk factors, including age (25-50 years), rural residency, lower socioeconomic status, female gender, direct contact with animals, and consumption of raw animal products. However, none of these factors reached statistical significance. The findings underscore the importance of continuous surveillance and targeted preventive measures to control brucellosis transmission between cattle and humans. Understanding the molecular prevalence and risk factors can guide public health strategies and improve livestock management practices to mitigate this zoonotic disease.
      Competing Interests: Declaration of Competing Interest The authors declares that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Brucella abortus; Brucella militensis; IS711; PCR; Prevalence; Risk factors
    • Publication Date:
      Date Created: 20241121 Date Completed: 20241128 Latest Revision: 20241128
    • Publication Date:
      20241202
    • Accession Number:
      10.1016/j.cimid.2024.102276
    • Accession Number:
      39571416