Causes and clinical characteristics of women with primary amenorrhea and ovarian or gonadal disorders at a quaternary hospital.

Publisher: Wiley on behalf of the Japan Society of Obstetrics and Gynecology] Country of Publication: Australia NLM ID: 9612761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1447-0756 (Electronic) Linking ISSN: 13418076 NLM ISO Abbreviation: J Obstet Gynaecol Res Subsets: MEDLINE

Publication: [Melbourne, Vic. : Wiley on behalf of the Japan Society of Obstetrics and Gynecology]
Original Publication: Tokyo : University of Tokyo Press, c1996-

Amenorrhea*/blood ; Amenorrhea*/etiology ; Turner Syndrome*/complications ; Turner Syndrome*/blood; Humans ; Female ; Adolescent ; Young Adult ; Retrospective Studies ; Adult ; Ovarian Diseases/blood ; Ovarian Diseases/complications ; Follicle Stimulating Hormone/blood ; Gonadal Dysgenesis, 46,XY/blood ; Gonadal Dysgenesis, 46,XY/complications

Aim: To evaluate the causes and clinical characteristics of primary amenorrhea and ovarian or gonadal disorders in women.
Methods: The medical records of all women evaluated for primary amenorrhea between January 2002 and December 2023 were retrospectively reviewed. Women with missing data were excluded from the study. Disorders of the ovary or gonads (hypergonadotropic hypogonadism) were defined as increased serum follicle-stimulating hormone (FSH) levels (>40 mIU/mL).
Results: Over a 21-year period, after excluding 1 woman with incomplete data, the study included 87 women who met the inclusion criteria. The median age at presentation was 18 years (interquartile range [IQR], 17-20). The median estradiol level was 5 pg/mL (IQR 5-10.4), and the median FSH level was 80 mIU/mL (IQR 63.1-94.9). The most common cause of primary amenorrhea was Turner syndrome (TS), followed by 46,XX and 46,XY gonadal dysgenesis. The median height was 147 cm (IQR, 140-158.7), and 50 women (57.5%) had karyotypic abnormalities, with TS being the most common abnormality.
Conclusion: TS was identified as the most common cause of primary amenorrhea with ovarian or gonadal disorders.
(© 2024 Japan Society of Obstetrics and Gynecology.)

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Keywords: abnormal karyotype; amenorrhea; gonadal failure; ovarian failure; turner syndrome

9002-68-0 (Follicle Stimulating Hormone)

Date Created: 20241121 Date Completed: 20241212 Latest Revision: 20241212

20241212

10.1111/jog.16165

39569531