Efficacy and safety of TiF 4 varnish in preventing erosive tooth wear in a rat animal model.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
      Rats, Wistar* ; Titanium* ; Fluorides* ; Disease Models, Animal*; Animals ; Male ; Rats ; Tooth Erosion/prevention & control ; Tooth Erosion/pathology ; Tooth Wear/pathology ; Fluorides, Topical/administration & dosage ; Sodium Fluoride ; Microscopy, Electron, Scanning ; Microscopy, Confocal
    • Abstract:
      An animal model was applied to develop erosive tooth wear (ETW) and to evaluate the efficacy and safety of titanium tetrafluoride (TiF 4 ) in preventing ETW. Forty-eight male Wistar rats were divided into three groups (n = 16): TiF 4 (2.45% F - ), NaF (2.45% F - ) and placebo varnishes. Eight from each group were subjected to erosive challenges (Sprite Zero) and the other received tap water, both ad libitum. After twenty-eight days, the mandibles were resected for histopathological gingival analysis, clinical and microscopic tooth evaluation by 3D confocal laser microscopy, scanning electron microscopy (SEM-EDX) and micro-Raman spectroscopy (MRS). Organs were evaluated with respect to fluoride content. No significant difference was found in F content in tissues. No histopathological damage was seen in gingiva. ETW was clinically more aggressive in rats from placebo group consuming Sprite compared to water (Q²=12.6, p < 0.01), in accordance with confocal images. TiF 4 was superior in reducing cross-section area loss (0.036 ± 0.01µm 2 ) compared to NaF and placebo, respectively (0.044 ± 0.01/0.063 ± 0.01µm 2 , ANOVA, p < 0.0001). Dentin exposure was detected by SEM in rats belonging to placebo consuming Sprite. Peaks compatible with typical apatite bands were visible. TiF 4 reduces the progression of ETW without causing any relevant side-effect and the rats' model was able to simulate ETW in vivo.
      Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
      (© 2024. The Author(s).)
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    • Grant Information:
      2019/21801-8 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2022/13803-3 Fundação de Amparo à Pesquisa do Estado de São Paulo
    • Contributed Indexing:
      Keywords: Erosion; Fluoride; Titanium; Tooth erosion
    • Accession Number:
      T08RW8YRG1 (titanium tetrafluoride)
      D1JT611TNE (Titanium)
      Q80VPU408O (Fluorides)
      0 (Fluorides, Topical)
      8ZYQ1474W7 (Sodium Fluoride)
    • Publication Date:
      Date Created: 20241120 Date Completed: 20241120 Latest Revision: 20241125
    • Publication Date:
      20241126
    • Accession Number:
      PMC11579421
    • Accession Number:
      10.1038/s41598-024-80449-4
    • Accession Number:
      39567633