Investigating the associations between uncarboxylated matrix gla protein as a proxy for vitamin K status and cardiovascular disease risk factors in a general adult population.

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  • Additional Information
    • Source:
      Publisher: Steinkopff Country of Publication: Germany NLM ID: 100888704 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-6215 (Electronic) Linking ISSN: 14366207 NLM ISO Abbreviation: Eur J Nutr Subsets: MEDLINE
    • Publication Information:
      Original Publication: Darmstadt, Germany : Steinkopff, 1999-
    • Subject Terms:
      Matrix Gla Protein* ; Extracellular Matrix Proteins*/blood ; Calcium-Binding Proteins*/blood ; Vitamin K*/blood ; Cardiovascular Diseases*/epidemiology ; Cardiovascular Diseases*/blood; Humans ; Middle Aged ; Male ; Female ; Adult ; Cross-Sectional Studies ; Aged ; Denmark/epidemiology ; Heart Disease Risk Factors ; Young Adult ; Risk Factors ; Biomarkers/blood ; Vitamin K Deficiency/blood ; Vitamin K Deficiency/complications ; Nutritional Status
    • Abstract:
      Purpose: Vitamin K is an activator of vitamin K dependent proteins, one of which is the potent inhibitor of vascular calcification, matrix Gla protein (MGP). The purpose of this study is to investigate the association between an inverse proxy of functional vitamin K status, plasma dephospho-uncarboxylated MGP (dp-ucMGP), and cardiovascular disease risk factors (CVDRFs).
      Methods: In a cross-sectional population-based health examination study of 4,092 individuals aged 24-77 years, the vitamin K status was assessed using plasma dp-ucMGP. All participants were linked to Danish National Prescription Register to obtain information on the use of vitamin K antagonists. The associations between log2 transformed dp-ucMGP values and CVDRFs were determined using regression models adjusted for sex, age, lifestyle factors, kidney function and waist circumference.
      Results: Higher dp-ucMGP levels were associated with increased risk of central obesity (Odds Ratio (OR) 4.76, 95% Confidence Intervals (CI) 3.57-6.34), diabetes (OR 1.96, 95% CI 1.11-3.45), hyperlipidaemia (OR 1.43, 95% CI 1.01-2.03), and impaired kidney function (OR 9.83, 95% CI 5.49-17.59) per doubling in dp-ucMGP. Dp-ucMGP was not independently associated with hypertension or arterial stiffness.
      Conclusion: Higher dp-ucMGP levels were associated with central obesity, diabetes, hyperlipidaemia, and impaired kidney function. Prospective studies and intervention studies examining the effects of improving vitamin K status are needed to clarify the potential role of vitamin K in relation to these CVDRFs.
      Competing Interests: Declarations. Conflict of interest: A. Linneberg has received an unrestricted grant and investigational products from Kappa Bioscience A/S for an intervention trial (The InterVitaminK Trial; clinicatrials.gov identifier NCT05259046) using vitamin K supplements as the active intervention. The remaining other authors declare no personal or financial conflict of interest.
      (© 2024. The Author(s).)
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    • Grant Information:
      F-12815-03-14-01 Danmarks Frie Forskningsfond; 7-11-0213 TrygFonden; 117548 TrygFonden; R155-2013-14070 Lundbeck Foundation; 22-B-0583 Helsefonden
    • Contributed Indexing:
      Keywords: Atherosclerosis; Cardiovascular disease risk factors; Epidemiology; Matrix Gla protein; Vitamin K
    • Accession Number:
      0 (Matrix Gla Protein)
      0 (Extracellular Matrix Proteins)
      0 (Calcium-Binding Proteins)
      12001-79-5 (Vitamin K)
      0 (Biomarkers)
    • Publication Date:
      Date Created: 20241120 Date Completed: 20241120 Latest Revision: 20241123
    • Publication Date:
      20241123
    • Accession Number:
      PMC11579057
    • Accession Number:
      10.1007/s00394-024-03532-6
    • Accession Number:
      39567396