The role of the dopamine D1 receptor in anticipatory pleasure and social play.

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  • Additional Information
    • Source:
      Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Pergamon Press
      Original Publication: Oxford, New York, Pergamon.
    • Subject Terms:
      Receptors, Dopamine D1*/genetics ; Receptors, Dopamine D1*/metabolism ; Receptors, Dopamine D1*/physiology ; Social Behavior* ; Pleasure*/physiology ; Play and Playthings*/psychology ; Anticipation, Psychological*/physiology; Animals ; Male ; Rats ; Vocalization, Animal/physiology ; Rats, Transgenic
    • Abstract:
      Social play is a highly rewarding activity seen across mammalian species that is vital for neurobehavioural development. Dysfunctions in social play are seen across psychiatric and neurodevelopmental disorders positing the importance of understanding the neurobiological mechanisms underlying social play. A multitude of neurotransmitter systems have been implicated in social play, with the present study focused on the role of dopamine, specifically the dopamine D1 receptor. Pharmacological manipulations of dopamine and the D1 receptor reveal mixed findings. Given the limited selectivity of pharmacological tools, we explored the role of the dopamine D1 receptor in social play using dopamine D1 mutant (DAD1 -/- ) rats which have a genetic reduction in functional D1 receptors. Aligning with the rewarding properties of social play, the present study also examined anticipatory behaviour for the opportunity to engage in social play. Contrary to our predictions, DAD1 -/- mutants initiated and engaged in social play similarly to wildtype controls with only subtle differences in specific elements of play behaviour. Subjects did not differ in 50 kHz vocalisations emitted during play, suggesting similar levels of consummatory pleasure. Although subjects initiated and engaged in play similarly, as predicted, DAD1 -/- mutants displayed deficits in anticipatory behaviour and pleasure for the opportunity to engage in social play. These findings support a prominent role of the D1 receptor in anticipatory behaviour, with further research needed to elucidate its role in social play.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
    • Contributed Indexing:
      Keywords: Anticipatory behaviour; D1 receptor; Dopamine; Social play
    • Accession Number:
      0 (Receptors, Dopamine D1)
      0 (Drd1 protein, rat)
    • Publication Date:
      Date Created: 20241120 Date Completed: 20241210 Latest Revision: 20241210
    • Publication Date:
      20241211
    • Accession Number:
      10.1016/j.neuropharm.2024.110225
    • Accession Number:
      39566573