Cooperative SIR dynamics as a model for spontaneous blood clot initiation.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Greulich P;Greulich P;Greulich P
  • Source:
    Journal of theoretical biology [J Theor Biol] 2025 Feb 07; Vol. 598, pp. 111991. Date of Electronic Publication: 2024 Nov 17.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: England NLM ID: 0376342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8541 (Electronic) Linking ISSN: 00225193 NLM ISO Abbreviation: J Theor Biol Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: London.
    • Subject Terms:
      Blood Coagulation*/physiology ; Blood Platelets*/physiology ; Platelet Activation*/physiology; Humans ; Models, Biological ; Thrombosis/blood ; Signal Transduction ; Animals
    • Abstract:
      Blood clotting is an important physiological process to suppress bleeding upon injury, but when it occurs inadvertently, it can cause thrombosis, which can lead to life threatening conditions. Hence, understanding the microscopic mechanistic factors for inadvertent, spontaneous blood clotting, in absence of a vessel breach, can help in predicting and averting such conditions. Here, we present a minimal model - reminiscent of the SIR model - for the initiating stage of spontaneous blood clotting, the collective activation of blood platelets. This model predicts that in the presence of very small initial activation signals, collective activation of the platelet population is possible, but requires a sufficient degree of heterogeneity of platelet sensitivity. To propagate the activation signal and achieve collective activation of the bulk platelet population, it requires the presence of, possibly only few, hyper-sensitive platelets, but also a sufficient proportion of platelets with intermediate, yet higher-than-average sensitivity. A comparison with experimental results demonstrates a qualitative agreement for high platelet signalling activity.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 The Author. Published by Elsevier Ltd.. All rights reserved.)
    • Contributed Indexing:
      Keywords: Blood clotting; Collective phenomena; Heterogeneity; SIR model
    • Publication Date:
      Date Created: 20241119 Date Completed: 20241211 Latest Revision: 20241211
    • Publication Date:
      20241212
    • Accession Number:
      10.1016/j.jtbi.2024.111991
    • Accession Number:
      39561943