Melanoma sentinel lymph node biopsy in the modern era.

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  • Author(s): Dumitra T;Dumitra T; Faries MB; Faries MB
  • Source:
    Surgical oncology [Surg Oncol] 2024 Dec; Vol. 57, pp. 102162. Date of Electronic Publication: 2024 Nov 04.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9208188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3320 (Electronic) Linking ISSN: 09607404 NLM ISO Abbreviation: Surg Oncol Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier Science
      Original Publication: Oxford ; Boston : Blackwell Scientific Publications, c1992-
    • Subject Terms:
      Melanoma*/pathology ; Melanoma*/surgery ; Sentinel Lymph Node Biopsy*/methods ; Skin Neoplasms*/pathology ; Skin Neoplasms*/surgery; Humans ; Lymphatic Metastasis ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node/surgery ; Prognosis
    • Abstract:
      The initial route of metastasis for many cancers, including melanoma, is via regional lymphatic channels. This fact, recognized more than a century ago, has spurred tremendous interest in the optimal method of assessing and treating lymph nodes and eventually led to the development of lymphatic mapping and sentinel lymph node (SLN) biopsy. The potential utility of nodal treatment includes providing the most accurate staging or prognostic information and removing early metastases in order to halt the cascade of metastatic spread in an effort to save the patient's life. In the past, pathologic assessment of regional lymph nodes required removal of all regional nodes, a procedure that results in moderate levels of short and long-term morbidity. SLN biopsy allows not only a minimally invasive method of nodal assessment, but one more accurate than full node dissection as it permits more intensive pathologic scrutiny of the tissue. The question of the therapeutic effect of SLN biopsy has been a subject of much controversy. There is clear evidence that SLN biopsy improves relapse-free survival in melanoma, but its effect on melanoma-specific and overall survival remains less clear.
      (Copyright © 2024 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Elective lymph node dissection; Melanoma; Sentinel lymph node biopsy
    • Publication Date:
      Date Created: 20241118 Date Completed: 20241211 Latest Revision: 20241212
    • Publication Date:
      20241212
    • Accession Number:
      10.1016/j.suronc.2024.102162
    • Accession Number:
      39556928