Cholecystectomy Is a Risk Factor for Proximal Colon Cancer That May Also Relate to its Aggressiveness.

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  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 0376340 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8673 (Electronic) Linking ISSN: 00224804 NLM ISO Abbreviation: J Surg Res Subsets: MEDLINE
    • Publication Information:
      Publication: New York, NY : Academic Press
      Original Publication: Philadelphia [etc.]
    • Subject Terms:
      Cholecystectomy*/adverse effects ; Cholecystectomy*/statistics & numerical data ; Proto-Oncogene Proteins B-raf*/genetics ; Colonic Neoplasms*/pathology ; Colonic Neoplasms*/surgery ; Colonic Neoplasms*/epidemiology ; Colonic Neoplasms*/etiology; Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Risk Factors ; Proto-Oncogene Proteins p21(ras)/genetics ; Membrane Proteins/genetics ; Mutation ; GTP Phosphohydrolases/genetics ; Neoplasm Staging
    • Abstract:
      Introduction: There are studies with mixed conclusions about the role cholecystectomy plays as a risk factor for proximal colorectal cancer (CRC).
      Methods: We performed a multicenter retrospective cohort study where the records of patients with CRC were reviewed. Data was collected regarding affected colon subsegment (cecum, ascending, transverse, descending, sigmoid, or rectum, which were also combined into proximal or distal colon), history and time since cholecystectomy, histopathology reports (TNM classification and clinical stage), and KRAS, NRAS, and BRAF mutation analysis. Univariate and multivariate analysis adjusting for age, smoking history, body mass index, sex, and family history of cancer were performed. Logistical regression for statistical analysis was used to estimate the odds ratio for the association between cholecystectomy and tumor location.
      Results: Four hundred four cases were obtained, of which 52 previously had cholecystectomy. The date of surgery was recorded in 43 patients, with a 5 y median and an interquartile range of 1.5-14 y prior to CRC diagnosis. Both crude and adjusted odds ratio (2.86 and 2.42, respectively) confirmed an associated risk for developing proximal CRC after cholecystectomy. When proximal CRC cases with previous cholecystectomy were directly compared against proximal CRC without cholecystectomy and distal CRC cases, the former had a higher distribution of prevalence for T3, T4b, N1b, M1a, and M1c. KRAS mutation also presented its highest prevalence in this group with 33%.
      Conclusions: Cholecystectomy was related to the development of proximal CRC in all its subsegments, seemingly associated with higher stages at diagnosis. Close surveillance should be considered in patients who undergo cholecystectomy.
      (Copyright © 2024 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Aggressiveness; Ascending colon; Cholecystectomy; Clinical staging; KRAS; Proximal colon cancer; Risk factor
    • Accession Number:
      EC 2.7.11.1 (Proto-Oncogene Proteins B-raf)
      EC 2.7.11.1 (BRAF protein, human)
      0 (KRAS protein, human)
      EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
      EC 3.6.1.- (NRAS protein, human)
      0 (Membrane Proteins)
      EC 3.6.1.- (GTP Phosphohydrolases)
    • Publication Date:
      Date Created: 20241115 Date Completed: 20241213 Latest Revision: 20241213
    • Publication Date:
      20241214
    • Accession Number:
      10.1016/j.jss.2024.10.018
    • Accession Number:
      39547064