The association between eye movement characteristics and cognitive function in adolescents with major depressive disorder.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101723001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7506 (Electronic) Linking ISSN: 09254927 NLM ISO Abbreviation: Psychiatry Res Neuroimaging Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier
    • Subject Terms:
      Depressive Disorder, Major*/physiopathology ; Depressive Disorder, Major*/psychology ; Eye Movements*/physiology ; Attention*/physiology ; Saccades*/physiology ; Cognition*/physiology; Humans ; Adolescent ; Male ; Female ; Pursuit, Smooth/physiology ; Eye-Tracking Technology ; Fixation, Ocular/physiology
    • Abstract:
      Objective: This study aims to explore the relationship between eye movement characteristics and cognitive function in adolescents with major depressive disorder (MDD).
      Method: EyeLink 1000 eye tracker was used to obtain eye movement data in free-viewing and smooth pursuit tasks. Chi-square test and Mann-Whitney test were used for inter-group comparison of demographic and clinical data. Spearman correlation was used to analyze the correlation between eye movement characteristics and cognitive function.
      Results: Adolescents with MDD showed lower saccade amplitude in the free-viewing task and more fixations and saccades in the smooth pursuit task. In the free-viewing task, fixation count, saccade duration and saccade speed were found to be positively correlated with immediate memory and attention; fixation duration was negatively correlated with immediate memory. In the smooth pursuit task, saccade count was positively correlated with the faux pas test; fixation duration and saccade duration were significantly correlated with memory and attention.
      Conclusion: Adolescents with MDD showed abnormalities in several indices of eye movement, and altered eye movement variables were also correlated with cognitive deficits. Eye-tracking technology helps illustrate the diverse cognitive strategies employed by individuals during cognitive tasks, allowing researchers to explore subtle differences in cognitive processes.
      Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yammei Shen reports financial support was provided by National Natural Science Foundation of China. Yammei Shen reports financial support was provided by Hunan Provincial Natural Science Foundation of China. Yammei Shen reports financial support was provided by Scientific Research Launch Project for new employees of the Second Xiangya Hospital of Central South University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024. Published by Elsevier B.V.)
    • Contributed Indexing:
      Keywords: Adolescent; Cognitive functioning; Eye movement; Free-viewing task; Major depressive disorder; Smooth pursuit task
    • Publication Date:
      Date Created: 20241115 Date Completed: 20241202 Latest Revision: 20241202
    • Publication Date:
      20241204
    • Accession Number:
      10.1016/j.pscychresns.2024.111914
    • Accession Number:
      39546964