Psychoneuroimmunology of Mood Disorders.

Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

Publication: Totowa, NJ : Humana Press
Original Publication: Clifton, N.J. : Humana Press,

Psychoneuroimmunology*/methods ; Depressive Disorder, Major*/immunology ; Bipolar Disorder*/immunology; Humans ; Inflammation/immunology ; Mood Disorders/immunology ; Autoimmunity ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Immunosenescence

Recent research has shed light on the intricate relationship between mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BD), and inflammation. This chapter explores the complex interplay involving immune and metabolic dysfunction in the pathophysiology of these disorders, emphasizing their association with autoimmunity/inflammatory conditions, chronic low-grade systemic inflammation, T cell overactivation, and immunosenescence. This perspective underscores the notion that MDD and BD are not solely brain disorders, highlighting their nature as multi-system conditions.
(© 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)

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Keywords: Bipolar disorder; Cytokines; Depression; Immunometabolism; Immunosenescence; Inflammation; Mood disorders

Date Created: 20241115 Date Completed: 20241116 Latest Revision: 20241119

20241119

10.1007/978-1-0716-4200-9_4

39546225