Added-value of dynamic contrast-enhanced MRI to conventional MRI for the differentiation between inflammatory myofibroblastic tumor and squamous cell carcinoma in the sinonasal region.

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  • Additional Information
    • Source:
      Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 1302751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1920 (Electronic) Linking ISSN: 00283940 NLM ISO Abbreviation: Neuroradiology Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin, New York, Springer-Verlag.
    • Subject Terms:
      Contrast Media* ; Magnetic Resonance Imaging*/methods ; Carcinoma, Squamous Cell*/diagnostic imaging ; Carcinoma, Squamous Cell*/pathology; Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Diagnosis, Differential ; Adult ; Aged ; Paranasal Sinus Neoplasms/diagnostic imaging ; Paranasal Sinus Neoplasms/pathology ; Diffusion Magnetic Resonance Imaging/methods ; Sensitivity and Specificity
    • Abstract:
      Purpose: The purpose of this study was to evaluate the additional value of dynamic contrast-enhanced (DCE) MRI and diffusion weighted MRI (DWI) in differentiation between inflammatory myofibroblastic tumor (IMT) and squamous cell carcinoma (SCC) in the sinonasal cavity.
      Methods: Patients with pathologically proven IMT and SCC in the sinonasal region were enrolled in this retrospective study. All participants underwent conventional MRI and dynamic contrast-enhanced MRI, while a subset of them performed DWI. All the MRI parameters were independently analyzed by two investigators.
      Results: This retrospective study included 21 patients with IMT and 55 patients with SCC. Significant differences were found in the conventional MR imaging features including mass margin, T2 signal intensity and track sign of maxillary (p < 0.05). For DCE-MRI features, significant differences were found in progressive centripetal continual enhancement and CImax (p < 0.001 and p = 0.026, respectively). A marginal significant difference was found in ADC values between IMT (0.86 ± 0.59) and SCC (1.14 ± 0.25) (p = 0.061). The conventional MRI analysis revealed that the combination of mass margin and track sign of maxillary yielded an accuracy of 81.6%. Using a combination of progressive centripetal continual enhancement on DCE-MRI and track sign of maxillary in multivariate logistic regression analysis, the accuracy was elevated to 92.1%.
      Conclusion: The incorporation of DCE-MRI features into conventional MRI showed improved diagnostic performance in differentiating IMT from SCC in the sinonasal region. The novel progressive centripetal continual enhancement on DCE-MRI is the most effective feature of IMT.
      Competing Interests: Declarations. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Consent to participate: For this type of retrospective study formal consent is not required. Competing interests: The authors have no relevant financial or non-financial interests to disclose.
      (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
    • References:
      Butrynski JE, D’Adamo DR, Hornick JL et al (2010) Crizotinib in alk-rearranged inflammatory myofibroblastic tumor. N Engl J Med 363:1727–1733. (PMID: 10.1056/NEJMoa1007056209794723014292)
      Fletcher CD (2014) The evolving classification of soft tissue tumours - an update based on the new 2013 WHO classification. Histopathology 64:2–11. (PMID: 10.1111/his.1226724164390)
      Surabhi VR, Chua S, Patel RP et al (2016) Inflammatory myofibroblastic tumors: current update. Radiol Clin North Am 54:553–563. (PMID: 10.1016/j.rcl.2015.12.00527153788)
      Amin M, Ali R, Kennedy S, Timon C (2012) Inflammatory myofibroblastic tumor of the nose and paranasal sinuses masquerading as a malignancy. Ear, Nose, & Throat Journal 91:E1-3.
      Chow LQM (2020) Head and neck cancer. N Engl J Med 382:60–72. (PMID: 10.1056/NEJMra171571531893516)
      Kawaguchi M, Kato H, Tomita H et al (2017) Imaging characteristics of malignant sinonasal tumors. J Clin Med 6:116. (PMID: 10.3390/jcm6120116292110485742805)
      Yuan XP, Li CX, Cao Y et al (2012) Inflammatory myofibroblastic tumour of the maxillary sinus: CT and MRI findings. Clin Radiol 67:e53–57. (PMID: 10.1016/j.crad.2012.08.00222974570)
      Som PM, Brandwein MS, Maldjian C et al (1994) Inflammatory pseudotumor of the maxillary sinus: CT and MR findings in six cases. AJR Am J Roentgenol 163:689–692. (PMID: 10.2214/ajr.163.3.80798698079869)
      Wang X, Liu Y, Chen Q, Xian J (2019) Evaluation of multiparametric MRI differentiating sinonasal angiomatous polyp from malignant tumors. Neuroradiology 61:891–896. (PMID: 10.1007/s00234-019-02225-w31119344)
      Kerr DA, Thompson LDR, Tafe LJ et al (2021) Clinicopathologic and genomic characterization of inflammatory myofibroblastic tumors of the head and neck: highlighting a novel fusion and potential diagnostic pitfall. Am J Surg Pathol 45:1707–1719. (PMID: 10.1097/PAS.000000000000173534001695)
      Gao F, Zhong R, Li GH, Zhang WD (2014) Computed tomography and magnetic resonance imaging findings of inflammatory myofibroblastic tumors of the head and neck. Acta Radiologica (Stockholm, Sweden: 1987) 55:434–440.
      He CY, Dong GH, Yang DM, Liu HG (2015) Inflammatory myofibroblastic tumors of the nasal cavity and paranasal sinus: a clinicopathologic study of 25 cases and review of the literature. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German society for Oto-Rhino-Laryngology -. Head Neck Surg 272:789–797.
      Famuyide A, Juliano A, Moonis G (2021) MRI of sinonasal malignancies. Top Magn Reson Imaging 30:139–149. (PMID: 10.1097/RMR.000000000000028834096897)
      Ma W, Huang X, Xie N et al (2022) MRI characteristics and correlation with pathology of an unusual inflammatory myofibroblastic tumor of the bladder. BJR Case Rep 8:20220086. (PMID: 366325549809916)
      Coffin CM, Hornick JL, Fletcher CD (2007) Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including alk expression in atypical and aggressive cases. Am J Surg Pathol 31:509–520. (PMID: 10.1097/01.pas.0000213393.57322.c717414097)
      Gaddikeri S, Gaddikeri RS, Tailor T, Anzai Y (2016) Dynamic contrast-enhanced mr imaging in head and neck cancer: techniques and clinical applications. AJNR Am J Neuroradiol 37:588–595. (PMID: 10.3174/ajnr.A4458264278397960151)
      Song C, Cheng P, Cheng J et al (2020) Differential diagnosis of nasopharyngeal carcinoma and nasopharyngeal lymphoma based on DCE-MRI and RESOLVE-DWI. Eur Radiol 30:110–118. (PMID: 10.1007/s00330-019-06343-031372786)
    • Grant Information:
      82202100 National Natural Science Foundation of China; 2022YFC2404005 Key Technologies Research and Development Program of Anhui Province; DFL20190203 Beijing Municipal Administration of Hospitals' Ascent Plan
    • Contributed Indexing:
      Keywords: Dynamic contrast-enhanced MRI; Inflammatory myofibroblastic tumor; Nasal cavity; Paranasal sinus; Squamous cell carcinoma
    • Accession Number:
      0 (Contrast Media)
    • Publication Date:
      Date Created: 20241112 Date Completed: 20241202 Latest Revision: 20241202
    • Publication Date:
      20241204
    • Accession Number:
      10.1007/s00234-024-03498-6
    • Accession Number:
      39531078