Multicellular adaptation to electrophysiological perturbations analyzed by deterministic and stochastic bioelectrical models.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
    • Abstract:
      Cells can compensate a disruptive change in one ion channel by compensatory changes in other channels. We have simulated the adaptation of a multicellular aggregate of non-excitable cells to the electrophysiological perturbation produced by the external blocking of a cation channel. In the biophysical model employed, we consider that this blocking provokes a cell depolarization that opens a voltage-gated calcium channel, thus allowing toxic Ca 2+ levels. The cell adaptation to this externally-induced perturbation is ascribed to the multiplicity of channels available to keep the cell membrane potential within a physiological window. We propose that the cell depolarization provokes the upregulated expression of a compensatory channel protein that resets the cell potential to the correct polarized value, which prevents the calcium entry. To this end, we use two different simulation algorithms based on deterministic and stochastic methods. The simulations suggest that because of the local correlations coupling the cell potential to transcription, short-term bioelectrical perturbations can trigger long-term biochemical adaptations to novel stressors in multicellular aggregates. Previous experimental data on planarian flatworms' adaptation to a barium-containing environment is also discussed.
      Competing Interests: Competing interests M.L. is cofounder of the company Morphoceuticals Inc., which operates in the regenerative medicine and hopes to do regeneration by bioelectric technology. The authors declare no other competing interests.
      (© 2024. The Author(s).)
    • References:
      Cell. 2021 Apr 15;184(8):1971-1989. (PMID: 33826908)
      Front Cell Dev Biol. 2022 Feb 14;10:772230. (PMID: 35237593)
      J Exp Biol. 2015 Feb 15;218(Pt 4):515-25. (PMID: 25696815)
      Int J Dev Biol. 2018;62(6-7-8):537-550. (PMID: 29938765)
      Cell Mol Life Sci. 2023 May 8;80(6):142. (PMID: 37156924)
      Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2312521121. (PMID: 38285940)
      J Neurophysiol. 2017 Jun 1;117(6):2125-2136. (PMID: 28298298)
      J Theor Biol. 2023 Jan 21;557:111338. (PMID: 36343668)
      J R Soc Interface. 2008 Jan 6;5(18):129-33. (PMID: 17626003)
      Annu Rev Cell Dev Biol. 2015;31:231-47. (PMID: 26566112)
      Nat Commun. 2018 Dec 18;9(1):5377. (PMID: 30560870)
      iScience. 2023 Nov 04;26(12):108398. (PMID: 38034358)
      Adv Wound Care (New Rochelle). 2014 Feb 1;3(2):184-201. (PMID: 24761358)
      Sci Rep. 2022 Jun 2;12(1):9206. (PMID: 35654933)
      Development. 2019 Dec 20;146(24):. (PMID: 31862792)
      Cancers (Basel). 2015 May 22;7(2):849-75. (PMID: 26010603)
      iScience. 2019 Dec 20;22:147-165. (PMID: 31765995)
      Curr Biol. 2019 May 20;29(10):1683-1688.e2. (PMID: 31080077)
      Neuron. 2018 Mar 21;97(6):1315-1326.e3. (PMID: 29526554)
      Biophys J. 2019 Mar 5;116(5):948-961. (PMID: 30799071)
      Dev Neurobiol. 2017 May;77(5):643-673. (PMID: 27265625)
      Sci Rep. 2016 Oct 12;6:35201. (PMID: 27731412)
      Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13763-8. (PMID: 11698650)
      Cells. 2024 Jul 02;13(13):. (PMID: 38994988)
      Adv Sci (Weinh). 2024 May;11(20):e2307938. (PMID: 38526185)
      Front Physiol. 2015 Jan 19;5:519. (PMID: 25646081)
      Nature. 2015 Nov 5;527(7576):59-63. (PMID: 26503040)
      Neuron. 2014 May 21;82(4):809-21. (PMID: 24853940)
      Philos Trans R Soc Lond B Biol Sci. 2014 Feb 03;369(1638):20130094. (PMID: 24493742)
      Trends Biochem Sci. 2020 Apr;45(4):284-294. (PMID: 32008897)
      J Mater Chem B. 2015 Jul 7;3(25):5035-5039. (PMID: 32262456)
      Front Cell Neurosci. 2020 May 26;14:136. (PMID: 32528251)
      Biochim Biophys Acta Gen Subj. 2023 Oct;1867(10):130440. (PMID: 37527731)
      J Physiol. 1994 Nov 1;480 ( Pt 3):405-10. (PMID: 7869255)
      Elife. 2018 Apr 05;7:. (PMID: 29620524)
      Patterns (N Y). 2023 Apr 26;4(5):100737. (PMID: 37223267)
      Biophys J. 2001 Mar;80(3):1195-209. (PMID: 11222284)
      Nat Commun. 2017 Apr 21;8:14826. (PMID: 28429717)
      Front Cell Neurosci. 2021 Apr 07;15:596953. (PMID: 33897368)
      Nat Commun. 2018 Oct 5;9(1):4111. (PMID: 30291250)
      Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):1036-1045. (PMID: 27771293)
      Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2202104119. (PMID: 35486697)
      Biosystems. 2018 Nov;173:65-72. (PMID: 30268925)
      Annu Rev Biophys. 2021 May 6;50:447-468. (PMID: 33651949)
      Development. 2021 May 15;148(10):. (PMID: 33999994)
      Nat Commun. 2022 Nov 5;13(1):6681. (PMID: 36335122)
      Science. 2020 May 29;368(6494):993-1001. (PMID: 32467389)
      Prog Biophys Mol Biol. 2019 Dec;149:39-53. (PMID: 31255702)
      Front Microbiol. 2015 Apr 14;6:264. (PMID: 25926819)
      Nat Commun. 2018 Mar 8;9(1):998. (PMID: 29519998)
      Biophys J. 2017 May 23;112(10):2231-2243. (PMID: 28538159)
      Int J Mol Sci. 2015 Nov 24;16(11):27865-96. (PMID: 26610482)
      J Theor Biol. 2021 May 21;517:110596. (PMID: 33508328)
      Entropy (Basel). 2022 Jun 12;24(6):. (PMID: 35741540)
    • Grant Information:
      PID2022-139953NB-I00 Ministerio de Ciencia e Innovación; TWCF0606 United States TWCF TWCF; 103733-00001 Guy Foundation Family Trust
    • Accession Number:
      SY7Q814VUP (Calcium)
      0 (Ion Channels)
      0 (Calcium Channels)
    • Publication Date:
      Date Created: 20241111 Date Completed: 20241111 Latest Revision: 20241116
    • Publication Date:
      20241116
    • Accession Number:
      PMC11554804
    • Accession Number:
      10.1038/s41598-024-79087-7
    • Accession Number:
      39528615