Gitelman syndrome patient managed with amiloride during pregnancy and lactation.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100967793 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2369 (Electronic) Linking ISSN: 14712369 NLM ISO Abbreviation: BMC Nephrol Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2000-
    • Subject Terms:
      Gitelman Syndrome*/drug therapy ; Gitelman Syndrome*/complications ; Gitelman Syndrome*/diagnosis ; Amiloride*/therapeutic use ; Lactation* ; Pregnancy Complications*/drug therapy; Humans ; Female ; Pregnancy ; Young Adult ; Hypokalemia/chemically induced
    • Abstract:
      Gitelman Syndrome (GS) is a rare autosomal-recessive tubular disorder characterized by hypokalemia, hypomagnesemia, metabolic alkalosis, hyperreninemic hyperaldosteronism, and normotension. Management of GS during pregnancy is particularly challenging due to pregnancy-associated renal physiological changes and due to controversial safety profiles regarding teratogenicity of medications commonly used for GS management in non-pregnant patients. We report a case of a 20-year-old female patient diagnosed of GS who was treated with amiloride during pregnancy and lactation due to persistent hypokalemia resistant to oral supplementation therapy. Use of amiloride facilitated control of hypokalemia and hypomagnesemia in the mother without causing any noticeable side effects in the newborn.
      (© 2024. The Author(s).)
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    • Contributed Indexing:
      Keywords: Amiloride; Gitelman; Hypokalemia; Hypomagnesemia; Pregnancy
    • Accession Number:
      7DZO8EB0Z3 (Amiloride)
    • Publication Date:
      Date Created: 20241110 Date Completed: 20241110 Latest Revision: 20241125
    • Publication Date:
      20250114
    • Accession Number:
      PMC11550528
    • Accession Number:
      10.1186/s12882-024-03801-w
    • Accession Number:
      39521975