Iron homeostasis and neurodegeneration in the ageing brain: Insight into ferroptosis pathways.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford, UK : Elsevier Science, c2002-
    • Subject Terms:
      Ferroptosis*/physiology ; Iron*/metabolism ; Aging*/metabolism ; Aging*/physiology ; Aging*/pathology ; Neurodegenerative Diseases*/metabolism ; Neurodegenerative Diseases*/pathology ; Brain*/metabolism ; Brain*/pathology ; Homeostasis*/physiology; Humans ; Animals ; Signal Transduction/physiology
    • Abstract:
      Ageing is a major risk factor for various chronic diseases and offers a potential target for developing novel and broadly effective preventatives or therapeutics for age-related conditions, including those affecting the brain. Mechanisms contributing to ageing have been summarized as the hallmarks of ageing, with iron imbalance being one of the major factors. Ferroptosis, an iron-mediated lipid peroxidation-induced programmed cell death, has recently been implicated in neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). Addressing ferroptosis offers both opportunities and challenges for treating neurodegenerative diseases, though the specific mechanisms remain unclear. This research explores the key processes behind how ferroptosis contributes to brain ageing, with a focus on the complex signaling networks that are involved. The current article aims to uncover that how ferroptosis, a specific type of cell death, may drive age-related changes in the brain. Additionally, the article also unveils its role in neurodegenerative diseases, discussing how understanding these mechanisms could open up new therapeutic avenues.
      Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Ageing; Alzheimer’s disease; Ferroptosis; Iron Homeostasis; Neurodegenerative disease
    • Accession Number:
      E1UOL152H7 (Iron)
    • Publication Date:
      Date Created: 20241108 Date Completed: 20241201 Latest Revision: 20241209
    • Publication Date:
      20241210
    • Accession Number:
      10.1016/j.arr.2024.102575
    • Accession Number:
      39515619