Detecting biological motion signals in human and monkey superior colliculus: a subcortical-cortical pathway for biological motion perception.

Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Original Publication: [London] : Nature Pub. Group

Superior Colliculi*/physiology ; Superior Colliculi*/diagnostic imaging ; Motion Perception*/physiology ; Magnetic Resonance Imaging*/methods; Animals ; Humans ; Male ; Adult ; Macaca mulatta ; Female ; Brain Mapping/methods ; Photic Stimulation ; Young Adult ; Temporal Lobe/physiology ; Temporal Lobe/diagnostic imaging ; Macaca

Most vertebrates, including humans, are highly adept at detecting and encoding biological motion, even when it is portrayed by just a few point lights attached to the head and major joints. However, the function of subcortical regions in biological motion perception has been scarcely explored. Here, we investigate the role of the superior colliculus in local biological motion processing. Using high-field (3 T) and ultra-high-field (7 T) functional magnetic resonance imaging, we record the neural responses of the superior colliculus to scrambled point-light walkers (with local kinematics retained) in both humans and male macaque monkeys. Results show that the superior colliculus, especially the superficial layers, selectively responds to local biological motion. Furthermore, dynamic causal modeling analysis reveals a subcortical-cortical functional pathway that transmits local biological motion signals from the superior colliculus via the middle temporal visual complex to the posterior superior temporal sulcus in the human brain. These findings suggest the existence of a cross-species mechanism in the superior colliculus that facilitates the detection of local biological motion at the early stage of the visual processing stream.
(© 2024. The Author(s).)

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32430043 National Natural Science Foundation of China (National Science Foundation of China); 31830037 National Natural Science Foundation of China (National Science Foundation of China)

Date Created: 20241106 Date Completed: 20241106 Latest Revision: 20241109

20241109

PMC11542025

10.1038/s41467-024-53968-x

39505906