Evaluation of dose and anatomy variability for nasopharyngeal carcinoma radiotherapy with a new fully integrated CT-linac.

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  • Additional Information
    • Publication Information:
      Ahead of Print
    • Source:
      Publisher: Elsevier Science Country of Publication: United States NLM ID: 8908862 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4022 (Electronic) Linking ISSN: 18734022 NLM ISO Abbreviation: Med Dosim Subsets: MEDLINE
    • Publication Information:
      Publication: <2000->: New York, NY : Elsevier Science
      Original Publication: [Southwest Harbor, Me. : Beech Hill Pub.,
    • Abstract:
      The goal of this study was to investigate the variability of target volume and parotid gland dose distribution for nasopharyngeal carcinoma (NPC), and to explore the shifting patterns of parotid gland centroid and neck radius during radiotherapy. Twenty patients with NPC were enrolled. The target volume dose difference between planning dose and recalculated dose on weekly CT was analyzed. The recalculated doses on every weekly CT were cumulated to assess the difference between delivered dose and planning dose. The relationship of parotid gland centroid deviation with dose was studied, and the shrinking distances of neck radius were calculated for cervical vertebra 1, 2, 3 levels (C1, C2, C3). The ratio of GTVs and CTVs doses on weekly CTs to the doses on planning CT was all above 0.98; the dose of PTVs on weekly CT tended to decrease compared with planning. RMD was defined as the ratio of the mean dose of the left and right parotid glands (L-PG, R-PG) to the planning mean dose. The fitted relationships of RMD and the deviation of centroid (D) for L-PG and R-PG were: RMD=0.37*D+0.98 (R 2  = 0.62, p < 0.001) and RMD = 0.33*D+0.97 (R 2  = 0.72, p < 0.001), respectively. The order of neck radius shrinking distance at different levels was C1>C2=C3. In this study, we quantitatively analyzed the dosimetric variabilities of target volumes, and established linear models of parotid gland dose and its centroid deviation, which provides fractional and full-course dose evaluation during radiotherapy for NPC.
      Competing Interests: Declaration of Competing Interest The authors have no conflict of interest to declare.
      (Copyright © 2024 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Dose distribution; Nasopharyngeal carcinoma; Parotid gland; Target volume; Weekly CT
    • Publication Date:
      Date Created: 20241105 Latest Revision: 20241105
    • Publication Date:
      20241106
    • Accession Number:
      10.1016/j.meddos.2024.09.005
    • Accession Number:
      39500646