Advances research in porcine enteric coronavirus therapies and antiviral drugs.

Publisher: Taylor & Francis Country of Publication: England NLM ID: 7909485 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-5941 (Electronic) Linking ISSN: 01652176 NLM ISO Abbreviation: Vet Q Subsets: MEDLINE

Publication: 2011->: Abingdon, Oxfordshire : Taylor & Francis
Original Publication: The Hague, Boston : Published for the Royal Netherlands Veterinary Assn. by M. Nijhoff.

Antiviral Agents*/therapeutic use ; Antiviral Agents*/pharmacology ; Swine Diseases*/drug therapy ; Swine Diseases*/virology ; Coronavirus Infections*/drug therapy ; Coronavirus Infections*/veterinary ; Coronavirus Infections*/virology ; Porcine epidemic diarrhea virus*/drug effects; Animals ; Swine ; Deltacoronavirus/drug effects ; Transmissible gastroenteritis virus/drug effects ; Alphacoronavirus

The porcine enteric coronaviruses (PECs) currently reported include porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), and swine acute diarrhea syndrome coronavirus (SADS-CoV). In the absence of effective treatment, they can cause similar clinical characteristics including weight loss, sleepiness, vomiting, anorexia and fatal diarrhea in neonatal piglets, resulting in significant economic losses to the global pig industry. Although many studies on drugs for treating and combating PECs have been issued. There are still no specific drug targeting PECs and used in clinical production. Therefore, it is necessary to sort out and summarize the research on the treatment and anti PECs drugs, and further development of low toxicity and high efficiency drugs is needed. Here, we review the latest progress of anti PECs drugs, focus on the mechanism of anti PECs reaction of drug components, and try to clarify new strategies for effective control and elimination of PECs. These comprehensive and profound insights will help to further investigate, prevent and control the transmission of PECs infection.

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Keywords: PDCoV; PEDV; SADS-CoV; TGEV; antiviral drugs; therapy

0 (Antiviral Agents)

Swine acute diarrhea syndrome coronavirus

Date Created: 20241101 Date Completed: 20241101 Latest Revision: 20241107

20241107

PMC11536681

10.1080/01652176.2024.2421299

39484691