Unraveling the association between chronic inflammatory demyelinating polyradiculoneuropathy and peritoneal Dialysis.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100967793 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2369 (Electronic) Linking ISSN: 14712369 NLM ISO Abbreviation: BMC Nephrol Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2000-
    • Subject Terms:
      Polyradiculoneuropathy, Chronic Inflammatory Demyelinating*/epidemiology ; Peritoneal Dialysis*/adverse effects ; Kidney Failure, Chronic*/therapy ; Kidney Failure, Chronic*/complications; Humans ; Male ; Female ; Case-Control Studies ; Middle Aged ; Aged ; Risk Factors ; Parathyroid Hormone/blood ; Adult ; Taiwan/epidemiology
    • Abstract:
      Background: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare disease seen in the general population and has been reported as showing an increased incidence in the peritoneal dialysis (PD) population, as documented in case reports.
      Methods: We conducted a case-control study using data from the Taichung Veterans General Hospital electric medical record database from the years 2010 to 2023. We defined cases as CIDP with End-stage kidney disease (ESKD) and controls as without CIDP. A logistic regression analysis was used to investigate the association between CIDP and dialysis modality, age, gender, dialysis duration, plasma potassium > 5.5 mEq/L and < 2.5 mEq/L, and intact parathyroid hormone (i-PTH) > 613 pg/mL.
      Results: Our findings suggest that PD may be a risk factor in the ESKD population (Odds ratio: 5.125, C.I.: 1.078 ~ 24.372, p = 0.040) according to logistic regression analysis. Dialysis duration, gender, diabetes mellitus, HbA1c > 7%, hypokalemia, hyperkalemia, and hyperparathyroidism did not show an association with CIDP.
      Conclusion: There seems to be an association between PD and CIDP in this case-control study. Possible mechanisms may involve systemic inflammation induced by peritoneal dialysate exchange or the content of the dialysate. Further studies are still needed.
      (© 2024. The Author(s).)
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    • Grant Information:
      T1107805 Taichung Veterans General Hospital
    • Accession Number:
      0 (Parathyroid Hormone)
    • Publication Date:
      Date Created: 20241029 Date Completed: 20241029 Latest Revision: 20241031
    • Publication Date:
      20241031
    • Accession Number:
      PMC11514778
    • Accession Number:
      10.1186/s12882-024-03830-5
    • Accession Number:
      39468467