Relationship Between C-Peptide Levels, Clinical Features, and Serum Data in a Brazilian Type 1 Diabetes Population with Large Variations in Genomic Ancestry.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, [2000-
    • Subject Terms:
      Diabetes Mellitus, Type 1*/genetics ; Diabetes Mellitus, Type 1*/blood ; C-Peptide*/blood; Humans ; Female ; Male ; Brazil ; Adult ; Cross-Sectional Studies ; Adolescent ; Insulin/blood ; Insulin/metabolism ; Young Adult ; Child ; Middle Aged ; Insulin-Secreting Cells/metabolism ; Insulin-Secreting Cells/pathology
    • Abstract:
      Type 1 diabetes (T1D) is a chronic disease characterized by the immune-mediated destruction of the pancreatic beta cells responsible for insulin production. The secreted insulin and C-peptide are equimolar. Due to its longer half-life, C-peptide has become a safer means of assessing the pancreatic reserve. C-peptide levels were evaluated in a population of patients with T1D, focusing on the relationship between this variable and other factors. In addition, the influence of C-peptide on metabolic control and microvascular complications was investigated. This cross-sectional study included 95 patients who had been diagnosed with T1D at least five years earlier. These patients were evaluated using a clinical demographic survey, anthropometric data, laboratory tests, and fundoscopy. This study showed that 29.5% of patients had residual insulin secretion, which correlated directly with their age at diagnosis. No statistically significant differences in metabolic control or microvascular complications were observed between the C-peptide level groups. In addition, our results indicate that ancestry does not influence the persistence of residual C-peptide function in our highly mixed population. It is recommended that future research consider incorporating new variables, such as HLA and pancreatic autoimmunity, as factors that may influence residual β-cell function.
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    • Contributed Indexing:
      Keywords: C-peptide; genomic ancestry; microvascular complication; type 1 diabetes
    • Accession Number:
      0 (C-Peptide)
      0 (Insulin)
    • Publication Date:
      Date Created: 20241026 Date Completed: 20241026 Latest Revision: 20241028
    • Publication Date:
      20241028
    • Accession Number:
      PMC11508759
    • Accession Number:
      10.3390/ijms252011144
    • Accession Number:
      39456927