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Tomographic and Electron Microscopy Description of Two Bone-Substitute Xenografts for the Preservation of Dental Alveoli.
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- Additional Information
- Source:
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
- Publication Information:
Original Publication: Basel, Switzerland : MDPI, [2000-
- Subject Terms:
- Abstract:
After tooth extraction, bone levels in the alveoli decrease. Using a bone substitute can help minimize this bone loss. The substitute can be sourced from a human or animal donor or synthetically prepared. In this study, we aimed to address the following PICOS question: In patients needing dental alveolar preservation for implant placement, how does alveolar preservation using a bovine hydroxyapatite bone xenograft with collagen compare to a xenograft without collagen in terms of changes in alveolar height and width, bone density, and the characteristics of the bone tissue observed in biopsies taken at 6 months? We evaluated two xenograft-type bone substitutes for preserving post-extraction dental sockets using tomography and microscopy to answer that question. A total of 18 dental alveoli were studied: 11 preserved with a xenograft composed of apatite (InterOss) and 7 with a xenograft composed of apatite-collagen (InterOss Collagen). Tomographic controls were performed at 1 and 6 months, and microscopic studies were performed on 13 samples. The biopsies were examined with scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS). A Multivariate Analysis of Variance (MANOVA) was conducted in the statistical analysis, revealing a significant increase in bone density over time ( p = 0.04). Specifically, bone density increased from an average of 526.14 HU at 30 days to 721.96 HU at 60 days in collagen-free samples. However, no statistically significant differences in height or width were found between groups. The MANOVA results indicated that the overall model had a low predictive ability for height, width, and density variables (R-squared values were low), likely due to sample size limitations and the complexity of bone tissue dynamics. On the other hand, FTIR analysis revealed the presence of phosphate groups, carbonates, and amides I, II, and III, indicative of inorganic (hydroxyapatite) and organic (type I collagen) materials in the xenografts. TGA and DSC showed high thermal stability, with minimal mass loss below 150 °C. Finally, both xenografts were influential in alveolar bone regeneration after extraction without significant differences. The trend of increasing collagen density suggests an effect that requires further investigation. However, it is recommended that the sample size be increased to enhance the validity of the results.
- References:
Int J Biomater. 2021 Mar 29;2021:8828194. (PMID: 33859694)
Ann Anat. 2021 Sep;237:151722. (PMID: 33771659)
Clin Oral Implants Res. 2017 Jul;28(7):840-848. (PMID: 27335267)
Polymers (Basel). 2021 Aug 09;13(16):. (PMID: 34451183)
Ann Anat. 2018 Jul;218:7-17. (PMID: 29604387)
J Biomater Appl. 2018 Oct;33(4):566-575. (PMID: 30326803)
Maxillofac Plast Reconstr Surg. 2022 Jul 12;44(1):24. (PMID: 35821286)
Sci Rep. 2019 Jun 27;9(1):9314. (PMID: 31249316)
Clin Implant Dent Relat Res. 2021 Feb;23(1):107-116. (PMID: 33155422)
J Dent. 2020 Oct;101:103455. (PMID: 32828845)
Bioact Mater. 2021 Dec 26;15:68-81. (PMID: 35386354)
Front Physiol. 2018 Jul 19;9:960. (PMID: 30072920)
Membranes (Basel). 2022 Apr 20;12(5):. (PMID: 35629770)
Int J Oral Maxillofac Surg. 2014 Feb;43(2):251-60. (PMID: 23948358)
Micron. 2024 Apr;179:103608. (PMID: 38354449)
Int J Oral Maxillofac Surg. 2017 Feb;46(2):250-260. (PMID: 27839628)
Tissue Eng Regen Med. 2021 Jun;18(3):327-341. (PMID: 33929713)
Mater Today Bio. 2023 May 06;20:100660. (PMID: 37214545)
Biomaterials. 2001 Mar;22(6):571-5. (PMID: 11219721)
J Biotechnol. 2024 Sep 30;395:149-160. (PMID: 39357624)
Biomedicines. 2022 Sep 16;10(9):. (PMID: 36140407)
Polymers (Basel). 2022 Jun 30;14(13):. (PMID: 35808724)
J Craniofac Surg. 2018 Mar;29(2):e203-e209. (PMID: 29303859)
J Funct Biomater. 2022 Mar 09;13(1):. (PMID: 35323228)
Materials (Basel). 2017 May 17;10(5):. (PMID: 28772900)
Polymers (Basel). 2021 Feb 17;13(4):. (PMID: 33671329)
J Korean Assoc Oral Maxillofac Surg. 2020 Oct 31;46(5):361-366. (PMID: 33122463)
Arch Histol Cytol. 2005 Jun;68(2):103-13. (PMID: 16079456)
J Clin Periodontol. 2019 Jun;46 Suppl 21:103-123. (PMID: 30667525)
Clin Exp Dent Res. 2024 Jun;10(3):e875. (PMID: 38798121)
Mater Sci Eng C Mater Biol Appl. 2019 Apr;97:644-649. (PMID: 30678951)
Int J Oral Maxillofac Implants. 2022 Jan-Feb;37(1):98-102. (PMID: 35235626)
Organogenesis. 2012 Oct-Dec;8(4):114-24. (PMID: 23247591)
Molecules. 2022 Sep 06;27(18):. (PMID: 36144483)
Arch Oral Biol. 2015 May;60(5):768-75. (PMID: 25766469)
Int J Mol Sci. 2022 Feb 25;23(5):. (PMID: 35269686)
Biophys Chem. 1999 Jul 19;80(1):7-20. (PMID: 10457593)
Implant Dent. 2019 Aug;28(4):388-399. (PMID: 31344018)
Periodontol 2000. 2023 Jun;92(1):235-262. (PMID: 36580417)
- Grant Information:
CI 1921 Universidad del Valle; SigmaGraft SigmaGraft
- Contributed Indexing:
Keywords: bone substitutes; dental alveolus; tomography; xenografts
- Accession Number:
0 (Bone Substitutes)
9007-34-5 (Collagen)
91D9GV0Z28 (Durapatite)
- Publication Date:
Date Created: 20241026 Date Completed: 20241026 Latest Revision: 20241028
- Publication Date:
20241028
- Accession Number:
PMC11507575
- Accession Number:
10.3390/ijms252010942
- Accession Number:
39456723
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