The Effect of Nitric Oxide Supplied to the Sweep Gas of the Oxygenator on the Formation of Gaseous Microemboli during Cardiopulmonary Bypass (Experimental Study).

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  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
    • Publication Information:
      Publication: New York : Springer
      Original Publication: New York, Consultants Bureau.
    • Subject Terms:
      Nitric Oxide*/metabolism ; Cardiopulmonary Bypass*/adverse effects ; Embolism, Air*/etiology; Animals ; Female ; Swine ; Oxygenators ; Phosphopyruvate Hydratase/metabolism
    • Abstract:
      The effect of nitric oxide (NO) supplied to the sweep gas of the oxygenator on the formation of gaseous microemboli during cardiopulmonary bypass has been studied in animal experiments (female pigs). It was shown that NO added to the sweep gas of the oxygenator during cardiopulmonary bypass significantly decreased the number and volume of microemboli (the number of microemboli over 1 h of cardiopulmonary bypass was 1197 (568; 2436) vs 55,478 (15,217; 331,480) in the control; p=0.016). The decrease in the number and volume of all bubbles was accompanied by a significant decrease in the concentration of neuron-specific enolase, a marker of brain injury, 6 h after the end of cardiopulmonary bypass to 7.7 (7.5; 8.7) ng/ml vs 11.2 (9.2; 18.3) ng/ml in the group without NO (p=0.047).
      (© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
    • References:
      Vieira Junior FU, Antunes N, Vieira RW, Alvares LM, Costa ET. Hemolysis in extracorporeal circulation: relationship between time and procedures. Rev. Bras. Cir. Cardiovasc. 2012;27(4):535-541. https://doi.org/10.5935/1678-9741.20120095. (PMID: 10.5935/1678-9741.2012009523515726)
      Born F, Chen J, Thierfelder N, Günther S, Peterß S, Hagl C, König F. Microbubble activity during extra corporeal life support. Thorac. Cardiovasc. Surg. 2017;65(Suppl. 01):S1-S110. https://doi.org/10.1055/s-0037-1598758. (PMID: 10.1055/s-0037-1598758)
      Barak M, Katz Y. Microbubbles: pathophysiology and clinical implications. Chest. 2005;128(4):2918-2932. https://doi.org/10.1378/chest.128.4.2918. (PMID: 10.1378/chest.128.4.291816236969)
      Stehouwer MC, Legg KR, de Vroege R, Kelder JC, Hofman E, de Mol BA, Bruins P. Clinical evaluation of the air-handling properties of contemporary oxygenators with integrated arterial filter. Perfusion. 2017;32(2):118-125. https://doi.org/10.1177/0267659116664402. (PMID: 10.1177/026765911666440227516417)
      Reis EE, Menezes LD, Justo CC. Gaseous microemboli in cardiac surgery with cardiopulmonary bypass: the use of veno-arterial shunt as a preventive method. Rev. Bras. Cir. Cardiovasc. 2012;27(3):436-445. https://doi.org/10.5935/1678-9741.20120073. (PMID: 10.5935/1678-9741.2012007323288186)
      Segers T, Stehouwer MC, de Somer FMJJ, de Mol BA, Versluis M. Optical verification and in-vitro characterization of two commercially available acoustic bubble counters for cardiopulmonary bypass systems. Perfusion. 2018;33(1):16-24. https://doi.org/10.1177/0267659117722595. (PMID: 10.1177/026765911772259528766987)
      Bello V, Bodo E, Merlo S. Optical multi-parameter measuring system for fluid and air bubble recognition. Sensors (Basel). 2023;23(15):6684. https://doi.org/10.3390/s23156684. (PMID: 10.3390/s231566843757147010422303)
      Panov AV, Lokshin LS, Gubko AV. Influence of gas microembolism on plasma concentration of protein S-100 and neurospecific enolase during open heart surgery under cardiopulmonary bypass. Klin. Eksper. Khir. 2023;11(1):121-125. Russian. https://doi.org/10.33029/2308-1198-2023-11-1-121-125.
      Lokshin LS. Gas microembolism during extracorporeal circulation. Anesteziol. Reanimatol. 2015;(5):17-20. Russian.
      Redaelli S, Magliocca A, Malhotra R, Ristagno G, Citerio G, Bellani G, Berra L, Rezoagli E. Nitric oxide: Clinical applications in critically ill patients. Nitric Oxide. 2022;121:20-33. https://doi.org/10.1016/j.niox.2022.01.007. (PMID: 10.1016/j.niox.2022.01.0073512306110189363)
      Hataishi R, Rodrigues AC, Neilan TG, Morgan JG, Buys E, Shiva S, Tambouret R, Jassal DS, Raher MJ, Furutani E, Ichinose F, Gladwin MT, Rosenzweig A, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 2006;291(1):H379-H384. https://doi.org/10.1152/ajpheart.01172.2005. (PMID: 10.1152/ajpheart.01172.200516443673)
      Shen Z, Wang Z, Zhang J, Jing H. Hepatic injury in a rat cardiopulmonary bypass model. Interact. Cardiovasc. Thorac. Surg. 2008;7(1):18-22. https://doi.org/10.1510/icvts.2006.150979. (PMID: 10.1510/icvts.2006.15097917951269)
      Radovskiy AM, Bautin AE, Marichev AO, Osovskikh VV, Semenova NY, Artyukhina ZE, Murashova LA, Zinserling VA. NO addition during gas oxygenation reduces liver and kidney injury during prolonged cardiopulmonary bypass. Pathophysiology. 2023;30(4):484-504. https://doi.org/10.3390/pathophysiology30040037. (PMID: 10.3390/pathophysiology300400373787385710594502)
      Petrova NN, Kovaltsova RS, Dorofeykov VV, Mashek ON, Bautin AE, Tashkhanov DM. Mental disorders, psychological characteristics and markers of central nervous system damage in patients undergoing cardiac surgery with extracorporeal circulation. Nevrologicheskii Vestnik. 2016;(3):18-24. Russian.
      Datzmann T, Messerer DAC, Münz F, Hoff mann A, Gröger M, Mathieu R, Mayer S, Gässler H, Zink F, McCook O, Merz T, Scheuerle A, Wolfschmitt EM, Thebrath T, Zuech S, Calzia E, Asfar P, Radermacher P, Kapapa T. The effect of targeted hyperoxemia in a randomized controlled trial employing a long-term resuscitated, model of combined acute subdural hematoma and hemorrhagic shock in swine with coronary artery disease: An exploratory, hypothesis generating study. Front. Med. (Lausanne). 2022;9:971882. https://doi.org/10.3389/fmed.2022.971882.
    • Contributed Indexing:
      Keywords: cardiopulmonary bypass; gas embolism; neuron-specific enolase; nitric oxide
    • Accession Number:
      31C4KY9ESH (Nitric Oxide)
      EC 4.2.1.11 (Phosphopyruvate Hydratase)
    • Publication Date:
      Date Created: 20241023 Date Completed: 20241111 Latest Revision: 20241111
    • Publication Date:
      20241114
    • Accession Number:
      10.1007/s10517-024-06268-9
    • Accession Number:
      39443358