Negative effects of ketoprofen and meloxicam on distal cauda epidydimal duct contractions, testosterone levels, and sperm count in rats.

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  • Additional Information
    • Source:
      Publisher: Elsevier Urban & Partner Country of Publication: Poland NLM ID: 101160559 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2300-732X (Electronic) Linking ISSN: 1642431X NLM ISO Abbreviation: Reprod Biol Subsets: MEDLINE
    • Publication Information:
      Publication: <2013- > : Olsztyn, Poland : Elsevier Urban & Partner
      Original Publication: Olsztyn, Poland : Polish Society for Biology of Reproduction, c2001-
    • Subject Terms:
      Meloxicam*/pharmacology ; Ketoprofen*/pharmacology ; Testosterone*/blood ; Anti-Inflammatory Agents, Non-Steroidal*/pharmacology ; Epididymis*/drug effects ; Sperm Count*; Animals ; Male ; Rats ; Rats, Wistar ; Muscle Contraction/drug effects
    • Abstract:
      Ketoprofen and meloxicam, non-steroidal anti-inflammatory drugs widely used in clinical practice, lack comprehensive investigation regarding their impact on male reproductive health, particularly on epididymal duct contractions and sperm parameters. Therefore, this study investigated the negative effects of ketoprofen or meloxicam on the contractions of the epididymal duct, sperm parameters, and serum testosterone levels in rats. Firstly, we assessed the in vitro effects of ketoprofen or meloxicam (1-100 μM) on the contractions of the epididymal duct elicited by noradrenaline. Rats were also orally treated with 5 mg/kg ketoprofen or 1 mg/kg meloxicam for 15 days following evaluation of epididymal duct contractions, sperm parameters, and serum testosterone levels. In vitro exposure to meloxicam (100 μM), but not ketoprofen, significantly reduced the maximum effect of noradrenaline in epididymal duct. Moreover, in vivo administration of ketoprofen and meloxicam decreased testosterone levels, sperm production, and sperm count in the caput/corpus region of the rat epididymis. Conversely, the sperm count in the cauda epididymis remained unchanged in animals treated with both ketoprofen and meloxicam. Meloxicam, but not ketoprofen, caused a delay in sperm transit time in the cauda region of the epididymis. In vivo treatment with both ketoprofen or meloxicam hindered the noradrenaline-induced contractions in the epididymal duct. In conclusion, ketoprofen and meloxicam can modify sperm parameters by decreasing testosterone levels and the contractions of the epididymal duct isolated from the distal cauda region of the rat epididymis.
      Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Epididymal duct contraction; Ketoprofen; Meloxicam; Sperm parameters, testosterone levels
    • Accession Number:
      VG2QF83CGL (Meloxicam)
      90Y4QC304K (Ketoprofen)
      3XMK78S47O (Testosterone)
      0 (Anti-Inflammatory Agents, Non-Steroidal)
    • Publication Date:
      Date Created: 20241022 Date Completed: 20241208 Latest Revision: 20241208
    • Publication Date:
      20241210
    • Accession Number:
      10.1016/j.repbio.2024.100963
    • Accession Number:
      39437457