Targeting MuRF1 to Combat Skeletal Muscle Wasting in Cardiac Cachexia: Mechanisms and Therapeutic Prospects.

Publisher: International Scientific Information, Inc Country of Publication: United States NLM ID: 9609063 Publication Model: Electronic Cited Medium: Internet ISSN: 1643-3750 (Electronic) Linking ISSN: 12341010 NLM ISO Abbreviation: Med Sci Monit Subsets: MEDLINE

Publication: 2014- : Smithtown, NY : International Scientific Information, Inc.
Original Publication: Warsaw, Poland : Medical Science International

Cachexia*/metabolism ; Cachexia*/etiology ; Cachexia*/drug therapy ; Tripartite Motif Proteins*/metabolism ; Ubiquitin-Protein Ligases*/metabolism ; Muscle, Skeletal*/metabolism ; Muscle Proteins*/metabolism ; Muscular Atrophy*/metabolism ; Heart Failure*/complications ; Heart Failure*/metabolism; Humans ; Animals

Cardiac cachexia, the terminal stage of chronic heart failure, is characterized by severe systemic metabolic imbalances and significant weight loss, primarily resulting from skeletal muscle mass depletion. Despite the detrimental consequences, there is no standardized and clinically-approved intervention currently available for cardiac cachexia. In the context of cardiac cachexia, accelerated protein turnover, that is, inhibited protein synthesis and enhanced protein degradation, plays a crucial role in skeletal muscle wasting. This process is primarily mediated by various proteins encoded by atrogenes. Among them, the atrogene Trim63 (tripartite motif family 63) and its encoded protein MuRF1 have been extensively studied. This review article aims to elucidate the pathogenic mechanisms underlying skeletal muscle wasting in cardiac cachexia, describe the biochemical characteristics of MuRF1, and provide an overview of the investigation into MuRF1-targeting inhibitors. The ultimate goal is to offer novel strategies for the clinical treatment for skeletal muscle wasting associated with cardiac cachexia.

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0 (Tripartite Motif Proteins)
EC 2.3.2.27 (Ubiquitin-Protein Ligases)
0 (Muscle Proteins)
EC 2.3.2.27 (TRIM63 protein, human)

Date Created: 20241022 Date Completed: 20241022 Latest Revision: 20241028

20241028

PMC11512513

10.12659/MSM.945211

39434377