Epidural injection of hydromorphone for postoperative pain after episiotomy: a randomized controlled trial.

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  • Author(s): Lu Y;Lu Y; Liu S; Liu S; Jing S; Jing S; Peng W; Peng W; Lin Y; Lin Y
  • Source:
    Scientific reports [Sci Rep] 2024 Oct 21; Vol. 14 (1), pp. 24704. Date of Electronic Publication: 2024 Oct 21.
  • Publication Type:
    Journal Article; Randomized Controlled Trial
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
      Hydromorphone*/administration & dosage ; Pain, Postoperative*/drug therapy ; Pain, Postoperative*/etiology ; Episiotomy*/adverse effects; Humans ; Female ; Adult ; Pregnancy ; Injections, Epidural ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/therapeutic use ; Pain Measurement
    • Abstract:
      Perineal incision resulting in post-partum pain and impact on puerperal life was the focus of our study. We recruited postpartum mothers who had undergone vaginal delivery to receive labor analgesia and episiotomy with an epidural injection of 0.5 mg hydromorphone to assess the therapeutic effects of postpartum analgesia. The participants were randomly allocated into two groups: the control group (Group NS) received an epidural injection of an equal amount of saline, while the study group (Group HY) received an epidural injection of 0.5 mg hydromorphone. We collected relevant data from electronic medical records to compare the differences between the two groups. The intervention group demonstrated lower pain scores at 4, 8, 12, 16, and 24 h compared to the control group (p < 0.001). Additionally, a higher number of patients in the control group required pain medication (7 (15.9%) compared to 2 (4.7%)). The time to first analgesia request in group NS was earlier than that in group HY (8.94 ± 1.27 h compared to 16.96 ± 3.38 h). The study group experienced higher rates of vomiting (P = 0.002) and itching (P < 0.001). However, there were no differences between the two groups in terms of urinary retention, dyskinesia, respiratory depression, dizziness, or neonatal feeding. The epidural injection of 0.5 mg hydromorphone proved to be effective in alleviating pain caused by maternal episiotomy and did not negatively affect neonatal feeding.Clinical trial registration: http://www.chictr.org.cn/usercenter.aspx identifier: ChiCTR2200064687.
      (© 2024. The Author(s).)
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    • Grant Information:
      No. Z20210012 Health Commission of Guangxi Zhuang Autonomous Region Self-financed Scientific Research Project
    • Contributed Indexing:
      Keywords: Episiotomy; Hydromorphone; Labor analgesia; Neonatal feeding
    • Accession Number:
      Q812464R06 (Hydromorphone)
      0 (Analgesics, Opioid)
    • Publication Date:
      Date Created: 20241021 Date Completed: 20241021 Latest Revision: 20241024
    • Publication Date:
      20241024
    • Accession Number:
      PMC11494193
    • Accession Number:
      10.1038/s41598-024-75610-y
    • Accession Number:
      39433860