Continuous Wireless Telemetric Measurement of Intraocular Pressure (IOP), Ocular Perfusion Pressure (OPP), and Cerebrospinal Fluid Pressure (CSFP) in Nonhuman Primates (NHPs).

Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

Publication: Totowa, NJ : Humana Press
Original Publication: Clifton, N.J. : Humana Press,

Intraocular Pressure*/physiology ; Telemetry*/methods ; Telemetry*/instrumentation ; Cerebrospinal Fluid Pressure*/physiology; Animals ; Glaucoma/cerebrospinal fluid ; Glaucoma/physiopathology ; Glaucoma/diagnosis ; Tonometry, Ocular/methods ; Tonometry, Ocular/instrumentation ; Wireless Technology/instrumentation ; Primates ; Disease Models, Animal

Intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) telemetry in large animal models can be used to determine the exact IOP, CSFP, translaminar pressure, and translaminar pressure gradient exposure that each normal and treated eye is subjected to relative to its fellow eye. In this way, it is possible to determine the independent contributions of each of these parameters (mean and/or transient fluctuations) to the risk of both the onset and rate of progression of glaucoma. Importantly, we have shown that IOP and CSFP fluctuate continuously by up to 100% over the course of the day, so snapshot cage-side IOP measurements are unable to adequately capture the pressure in the eye; CSFP is not measurable noninvasively at all. Implementation of IOP and CSFP telemetry will allow us to precisely determine the pressure insult in each eye of each animal and thereby unravel the true mechanisms underlying pressure-induced damage to the retinal ganglion cells in glaucoma.
(© 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)

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Keywords: Intraocular pressure fluctuations; Lamina cribrosa; Long-term IOP monitoring; Mechanical stress

Date Created: 20241021 Date Completed: 20241021 Latest Revision: 20241129

20241202

10.1007/978-1-0716-4140-8_21

39433682