A tissue bandage for pelvic ganglia injury.

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  • Additional Information
    • Source:
      Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
    • Publication Information:
      Original Publication: [London] : Nature Pub. Group
    • Subject Terms:
      Bandages* ; Urinary Bladder, Neurogenic*/therapy ; Urinary Bladder, Neurogenic*/etiology; Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Pelvis/innervation ; Pelvis/injuries ; Ganglia/metabolism ; Urinary Bladder/innervation ; Wound Healing/physiology
    • Abstract:
      Neurogenic bladder often occurs after pelvic ganglia injury. Its symptoms, like severe urinary retention and incontinence, have a significant impact on individuals' quality of life. Unfortunately, there are currently no effective treatments available for this type of injury. Here, we designed a fiber-enhanced tissue bandage for injured pelvic ganglia. Tight junctions formed in tissue bandages create a mini tissue structure that enhances resistance in an in vivo environment and delivers growth factors to support the healing of ganglia. Strength fibers are similar to clinical bandages and guarantee ease of handling. Furthermore, tissue bandages can be stored at low temperatures over 5 months without compromising cell viability, meeting the requirements for clinical products. A tissue bandage was applied to a male rat with a bilateral major pelvic ganglia crush injury. Compared to the severe neurogenic bladder symptoms observed in the injury and scaffold groups, tissue bandages significantly improved bladder function. We found that tissue bandage increases resistance to mechanical injury by boosting the expression of cytoskeletal proteins within the major pelvic ganglia. Overall, tissue bandages show promise as a practical therapeutic approach for ganglia repair, offering hope for developing more effective treatments for this thorny condition.
      (© 2024. The Author(s).)
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    • Grant Information:
      No. 52325504 China National Funds for Distinguished Young Scientists; No. 52325504 China National Funds for Distinguished Young Scientists; No. 52235007 National Natural Science Foundation of China (National Science Foundation of China); T2121004 National Natural Science Foundation of China (National Science Foundation of China); No. 52235007 National Natural Science Foundation of China (National Science Foundation of China); T2121004 National Natural Science Foundation of China (National Science Foundation of China); No. 81971363 National Natural Science Foundation of China (National Science Foundation of China); No. 81971363 National Natural Science Foundation of China (National Science Foundation of China)
    • Publication Date:
      Date Created: 20241017 Date Completed: 20241017 Latest Revision: 20241020
    • Publication Date:
      20241020
    • Accession Number:
      PMC11487282
    • Accession Number:
      10.1038/s41467-024-53302-5
    • Accession Number:
      39419980