Cyclodextrin-Containing Drug Delivery Systems and Their Applications in Neurodegenerative Disorders.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Cyclodextrins*/chemistry ; Neurodegenerative Diseases*/drug therapy ; Neurodegenerative Diseases*/metabolism ; Drug Delivery Systems*/methods; Humans ; Blood-Brain Barrier/metabolism ; Animals ; Drug Carriers/chemistry

Cyclodextrins (CDs) are ubiquitous excipients, constituted of cyclic glucopyranose units, and possess a unique dual nature, that of a hydrophobic interior and a hydrophilic exterior. This enables their interaction with lipid-affinitive compounds and hydrophilic compounds, thereby augmenting their application in pharmaceutical formulations as agents for improving solubility, as well as fundamental elements of advanced drug delivery systems. Additionally, CDs, upon suitable modification, can strategically participate in the interaction with cellular components and physical barriers, such as the blood-brain barrier, where their intricate and multifunctional engagement leads to various biological impacts. This review consolidates the crucial features of CDs and their derivatives, and summarizes the applications of them as drug delivery systems in neurodegenerative disorders, emphasizing their notable potentials.

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82301093 National Natural Science Foundation of China

Keywords: cyclodextrin; drug delivery systems; neurodegenerative disorders

0 (Cyclodextrins)
0 (Drug Carriers)

Date Created: 20241016 Date Completed: 20241016 Latest Revision: 20241019

20241019

PMC11477047

10.3390/ijms251910834

39409162