Dissecting the roles of prosaposin as an emerging therapeutic target for tumors and its underlying mechanisms.

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  • Additional Information
    • Source:
      Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
    • Publication Information:
      Publication: Paris : Editions Scientifiques Elsevier
      Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982-
    • Subject Terms:
      Saposins*/metabolism ; Neoplasms*/drug therapy ; Neoplasms*/metabolism ; Neoplasms*/pathology; Humans ; Animals ; Signal Transduction/drug effects ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology ; Molecular Targeted Therapy
    • Abstract:
      As a dual-function protein, prosaposin (PSAP) is a lysosome-associated protein that participates in a variety of cellular processes. In the lysosome, PSAP is processed to activate enzymes that degrade lipids. In addition, PSAP proteins located extracellularly are involved in cancer progression, such as proliferation and tumor death suppression signaling. Moreover, under different situations, PSAP exhibits distinct metastasis potentials in tumors. However, comprehensive insight into PSAP in cancer progression has been lacking. Here, we provide a framework of the role of PSAP in cancer and its clinical application in cancer patients, providing a novel perspective on the clinical translation of PSAP.
      Competing Interests: Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
      (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
    • Contributed Indexing:
      Keywords: Application; Cancer; Extracellular; Hallmarks; PSAP; Therapeutic target
    • Accession Number:
      0 (Saposins)
      0 (PSAP protein, human)
      0 (Antineoplastic Agents)
    • Publication Date:
      Date Created: 20241015 Date Completed: 20241113 Latest Revision: 20241113
    • Publication Date:
      20241114
    • Accession Number:
      10.1016/j.biopha.2024.117551
    • Accession Number:
      39405903