Toxin-Antitoxin Systems Reflect Community Interactions Through Horizontal Gene Transfer.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: United States NLM ID: 8501455 Publication Model: Print Cited Medium: Internet ISSN: 1537-1719 (Electronic) Linking ISSN: 07374038 NLM ISO Abbreviation: Mol Biol Evol Subsets: MEDLINE
    • Publication Information:
      Publication: 2003- : New York, NY : Oxford University Press
      Original Publication: [Chicago, Ill.] : University of Chicago Press, [c1983-
    • Subject Terms:
      Gene Transfer, Horizontal* ; Toxin-Antitoxin Systems*/genetics ; Plasmids*/genetics; Bacteria/genetics
    • Abstract:
      Bacterial evolution through horizontal gene transfer (HGT) reflects their community interactions. In this way, HGT networks do well at mapping community interactions, but offer little toward controlling them-an important step in the translation of synthetic strains into natural contexts. Toxin-antitoxin (TA) systems serve as ubiquitous and diverse agents of selection; however, their utility is limited by their erratic distribution in hosts. Here we examine the heterogeneous distribution of TAs as a consequence of their mobility. By systematically mapping TA systems across a 10,000 plasmid network, we find HGT communities have unique and predictable TA signatures. We propose these TA signatures arise from plasmid competition and have further potential to signal the degree to which plasmids, hosts, and phage interact. To emphasize these relationships, we construct an HGT network based solely on TA similarity, framing specific selection markers in the broader context of bacterial communities. This work both clarifies the evolution of TA systems and unlocks a common framework for manipulating community interactions through TA compatibility.
      Competing Interests: Conflict of Interest The authors declare no competing financial interests.
      (© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.)
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    • Contributed Indexing:
      Keywords: community; horizontal gene transfer; network; plasmid; toxin–antitoxin system
    • Publication Date:
      Date Created: 20241015 Date Completed: 20241027 Latest Revision: 20241101
    • Publication Date:
      20241101
    • Accession Number:
      PMC11523183
    • Accession Number:
      10.1093/molbev/msae206
    • Accession Number:
      39404847