Bilobalide ameliorates osteoporosis by influencing the SIRT3/NF-κB axis in osteoclasts and promoting M2 polarization in macrophages.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: Guildford, Eng., IPC Science and Technology Press.
    • Subject Terms:
      Osteoclasts*/drug effects ; Osteoclasts*/metabolism ; Sirtuin 3*/metabolism ; Osteoporosis*/drug therapy ; Osteoporosis*/metabolism ; Osteoporosis*/pathology ; NF-kappa B*/metabolism ; Macrophages*/drug effects ; Macrophages*/metabolism ; Furans*/pharmacology ; Furans*/chemistry ; Signal Transduction*/drug effects; Animals ; Mice ; RAW 264.7 Cells ; RANK Ligand/metabolism ; Osteogenesis/drug effects ; Female ; Mice, Inbred C57BL ; Cyclopentanes ; Ginkgolides
    • Abstract:
      Osteoporosis is a systemic disease with complex etiology and high prevalence, resulting in a huge economic burden. For a long time, the search for new therapeutic pharmaceuticals has never stopped. Bone loss is related to the imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. In recent years, the role of immunity and inflammation in the development of osteoporosis has studied well. For example, various cytokines, chemokines and endocrine factors regulate osteoclastogenesis via activating different macrophage subtypes, including pro-inflammatory M1 and anti-inflammatory M2. Bilobalide (Bil), an active Ginkgo biloba ingredient, has garnered great interest because of its anti-oxidant and anti-inflammatory activities. In this study, we found that Bil can attenuate osteoclast generation induced by receptor activator of nuclear factor- kappa B ligand (RANKL) through upregulating the sirtuin 3 (SIRT3) and negatively regulating NF-κB signaling. Furthermore, Bil promotes M2 polarization of macrophages in a dose-dependent manner. In vivo studies provided evidence that Bil improves bone density in osteoporosis mice models. Based on the above results, we have reason to believe that Bil has potential therapeutic value in osteoclast-mediated bone loss and offers an effective option for long-term osteoporosis management.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Bilobalide; Macrophage polarization; Osteoclast; SIRT3
    • Accession Number:
      EC 3.5.1.- (Sirtuin 3)
      0 (NF-kappa B)
      0 (Furans)
      M81D2O8H7U (bilobalide)
      0 (RANK Ligand)
      0 (Sirt3 protein, mouse)
      0 (Cyclopentanes)
      0 (Ginkgolides)
    • Publication Date:
      Date Created: 20241012 Date Completed: 20241116 Latest Revision: 20241116
    • Publication Date:
      20241118
    • Accession Number:
      10.1016/j.ijbiomac.2024.136504
    • Accession Number:
      39395513