Preparation of biocompatible Zein/Gelatin/Chitosan/PVA based nanofibers loaded with vitamin E-TPGS via dual-opposite electrospinning method.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Zein*/chemistry ; Nanofibers*/chemistry ; Vitamin E*/chemistry ; Vitamin E*/pharmacology ; Gelatin*/chemistry ; Chitosan*/chemistry ; Polyvinyl Alcohol*/chemistry ; Biocompatible Materials*/chemistry ; Biocompatible Materials*/pharmacology ; Staphylococcus aureus*/drug effects; Bandages ; Humans ; Escherichia coli/drug effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry

Wound management is a critical aspect of healthcare, necessitating effective and innovative wound dressing materials. Many existing wound dressings lack effectiveness and exhibit limitations, including poor antimicrobial activity, toxicity, inadequate moisture regulation, and weak mechanical performance. The aim of this study is to develop a natural-based nanofibrous structure that possesses desirable characteristics for use as a wound dressing. The chemical analysis confirmed the successful creation of Zein (Ze) (25% w/v) /gelatin (Gel) (10% w/v) /chitosan (CS) (2% w/v) /Polyvinyl alcohol (PVA) (10% w/v) nanofibrous scaffolds loaded with vitamin E tocopheryl polyethylene glycol succinate (Vit E). The swelling percentages of nanofiber (NF), NF + Vit E, cross-linked nanofiber (CNF), and CNF + Vit E were 49%, 110%, 410%, and 676%, respectively; and the degradation rates of NF, NF + Vit E, CNF, and CNF + Vit E were 29.57 ± 5.06%, 33.78 ± 7.8%, 14.03 ± 7.52%, 43 ± 6.27%, respectively. The antibacterial properties demonstrated that CNF impregnated with antibiotics reduced Escherichia coli (E. coli) counts by approximately 27-28% and Staphylococcus aureus (S. aureus) counts by about 34-35% compared to negative control. In conclusion, cross-linked Ze/Gel/CS/PVA nanofibrous scaffolds loaded with Vit E have potential as suitable wound dressing materials because environmentally friendly materials contribute to sustainable wound care and controlled degradation ensures wound dressings breakdown harmlessly.
(© 2024. The Author(s).)

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Keywords: Chitosan; Electrospinning; Gelatin; Nanofibers; Zein

9010-66-6 (Zein)
1406-18-4 (Vitamin E)
9000-70-8 (Gelatin)
9012-76-4 (Chitosan)
9002-89-5 (Polyvinyl Alcohol)
0 (Biocompatible Materials)
0 (Anti-Bacterial Agents)
O03S90U1F2 (tocophersolan)

Date Created: 20241011 Date Completed: 20241011 Latest Revision: 20241015

20241015

PMC11470087

10.1038/s41598-024-74865-9

39394234