Bacteria renew an OLD protein to cleave host tRNAs and block phage translation.

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  • Author(s): Gibbs KD;Gibbs KD; LeRoux M; LeRoux M
  • Source:
    Cell host & microbe [Cell Host Microbe] 2024 Oct 09; Vol. 32 (10), pp. 1639-1641.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cambridge, Mass. : Cell Press
    • Subject Terms:
      RNA, Transfer*/metabolism ; Bacteriophages*/genetics ; Bacteriophages*/metabolism; Bacteria/virology ; Bacteria/metabolism ; Bacteria/genetics ; Toxin-Antitoxin Systems ; Virus Replication ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Protein Biosynthesis
    • Abstract:
      Anti-phage defenses must rapidly sense and respond to diverse viruses. A recent pair of papers in Nature reveal via structural and functional assays how the PARIS defense system, a recently discovered toxin-antitoxin system, senses phage-associated molecular patterns (PhAMPs), thereby activating an endonuclease toxin that cleaves tRNA to block phage replication.
      Competing Interests: Declaration of interests The authors declare no competing interests.
      (Copyright © 2024 Elsevier Inc. All rights reserved.)
    • Accession Number:
      9014-25-9 (RNA, Transfer)
      0 (Bacterial Proteins)
    • Publication Date:
      Date Created: 20241010 Date Completed: 20241010 Latest Revision: 20241010
    • Publication Date:
      20241011
    • Accession Number:
      10.1016/j.chom.2024.09.006
    • Accession Number:
      39389024