Superficial ice and deep blaze: A defense strategy of the skin.

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  • Author(s): Qiu Z;Qiu Z;Qiu Z; Li W; Li W
  • Source:
    Immunity [Immunity] 2024 Oct 08; Vol. 57 (10), pp. 2263-2265.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
    • Publication Information:
      Publication: Cambridge, MA : Cell Press
      Original Publication: Cambridge, Mass. : Cell Press, c1994-
    • Subject Terms:
      Keratinocytes*/metabolism ; Keratinocytes*/immunology ; Skin*/immunology ; Skin*/metabolism ; Transcription Factors*/metabolism; Humans ; Animals ; Histone Demethylases/metabolism ; Epidermis/metabolism ; Epidermis/immunology ; Receptors, Pattern Recognition/metabolism ; DNA-Binding Proteins/metabolism
    • Abstract:
      It's crucial for skin to establish efficient defense strategies. Liu et al. reveal that the transcription factor ZNF750 recruits the histone demethylase KDM1A to silence pattern recognition receptors in the outer epidermis, making their expression limited to deeper, undifferentiated keratinocytes to address threats penetrating the skin.
      Competing Interests: Declaration of interests The authors declare no competing interests.
      (Copyright © 2024 Elsevier Inc. All rights reserved.)
    • Accession Number:
      0 (Transcription Factors)
      EC 1.14.11.- (Histone Demethylases)
      0 (Receptors, Pattern Recognition)
      EC 1.5.- (KDM1A protein, human)
      0 (DNA-Binding Proteins)
    • Publication Date:
      Date Created: 20241009 Date Completed: 20241009 Latest Revision: 20241009
    • Publication Date:
      20241010
    • Accession Number:
      10.1016/j.immuni.2024.09.008
    • Accession Number:
      39383842