Maternal exposure to glyphosate increased the risk of adverse neurodevelopmental outcomes in rodent offspring: A systematic review.

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  • Additional Information
    • Source:
      Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6424 (Electronic) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ Pollut Subsets: MEDLINE
    • Publication Information:
      Original Publication: Barking, Essex, England : Elsevier Applied Science Publishers, c1987-
    • Subject Terms:
      Glyphosate* ; Glycine*/analogs & derivatives ; Glycine*/toxicity ; Herbicides*/toxicity ; Prenatal Exposure Delayed Effects* ; Rodentia* ; Maternal Exposure*; Animals ; Female ; Pregnancy ; Neurodevelopmental Disorders/chemically induced ; Environmental Pollutants/toxicity ; Rats ; Brain/drug effects ; Brain/metabolism ; Brain/growth & development ; Mice
    • Abstract:
      The potential neurotoxicity of environmental contaminants, such as pesticides, is implicated in the etiology of neurodevelopmental disorders, particularly given the heightened vulnerability of the developing brain. Among these contaminants, glyphosate, a widely used herbicide, has been linked to alterations in neurodevelopment, though its precise neurotoxic mechanisms are not fully elucidated. In this context, our systematic review evaluates the impact of maternal exposure to glyphosate alone (GLY) or glyphosate-based-herbicide (GBH) on neurodevelopmental and behavioral outcomes in rodent offspring. This assessment encompasses a comprehensive examination of behavioral, biochemical, morphological, and genetic alterations resulting from perinatal glyphosate exposure. The Systematic review protocol was registered in the platform Open Science Framework (OSF) following the guidelines of the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE). Our analysis demonstrate that glyphosate disrupts redox signaling, metabolic pathways, and neurotransmitter systems, thereby affecting brain architecture and function across genders and developmental stages in rodents. The results of this review elucidate the extensive neurochemical and behavioral disruptions attributed to glyphosate, highlighting the critical need for advanced neurodevelopmental risk assessment methodologies. Such refined evaluations are vital to inform targeted prevention and intervention strategies in the context of environmental neurotoxicants.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Glyphosate; Inflammation; Neurodevelopment; Neurotoxicology; Oxidative stress; Pesticide
    • Accession Number:
      4632WW1X5A (Glyphosate)
      TE7660XO1C (Glycine)
      0 (Herbicides)
      0 (Environmental Pollutants)
    • Publication Date:
      Date Created: 20241007 Date Completed: 20241127 Latest Revision: 20241127
    • Publication Date:
      20241202
    • Accession Number:
      10.1016/j.envpol.2024.125086
    • Accession Number:
      39374765