Sociodemographic and dietary determinants of glyphosate exposure in a NYC-based pregnancy cohort.

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  • Additional Information
    • Source:
      Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6424 (Electronic) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ Pollut Subsets: MEDLINE
    • Publication Information:
      Original Publication: Barking, Essex, England : Elsevier Applied Science Publishers, c1987-
    • Subject Terms:
      Glycine*/analogs & derivatives ; Glycine*/urine ; Glyphosate* ; Diet*/statistics & numerical data ; Herbicides*/urine; Humans ; Female ; Pregnancy ; Adult ; Cohort Studies ; New York City ; Young Adult ; Sociodemographic Factors ; Maternal Exposure/statistics & numerical data ; Socioeconomic Factors ; Organophosphonates
    • Abstract:
      Previous studies have provided evidence for associations between glyphosate and aminomethylphosphonic acid (AMPA) exposure and adverse birth outcomes. However, few pregnancy cohort studies have investigated dietary and other determinants of glyphosate and AMPA exposure. We aimed to identify dietary and sociodemographic factors that predict glyphosate and AMPA exposure in a contemporary, urban pregnancy cohort in the US. The study included 725 pregnant participants from the New York University Children's Health and Environment Study (NYU CHES) in New York City. Urinary concentrations of glyphosate and AMPA, determined by high-performance liquid chromatography and tandem mass spectrometry, were analyzed in urine collected from NYU CHES participants across three prenatal time points. The Diet Health Questionnaire II was completed to capture dietary intake during the prenatal period. Descriptive statistics and bivariate linear models were used to assess determinants of urinary glyphosate and AMPA concentrations. Median urinary glyphosate and AMPA levels were 0.36 ng/mL and 0.37 ng/mL, respectively. Lower glyphosate levels were associated with younger age, obesity, public insurance, being single, and lower educational attainment. Nuts, seeds and whole grain intake was associated with increased urinary glyphosate concentrations. Urinary glyphosate concentrations were lower in summer than in winter. The study findings highlight widespread exposure to glyphosate and AMPA in this pregnancy cohort, with nuts/seeds and whole grains identified as possible dietary sources of exposure. High detection rates in the study population necessitate further research on dietary exposure patterns and perinatal outcomes to inform targeted interventions and reduce exposure in vulnerable populations.
      Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Whitney Cowell reports financial support was provided by National Institute of Environmental Health Sciences. Leonardo Trasande reports financial support was provided by National Institute of Health. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Ltd. All rights reserved.)
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    • Grant Information:
      R00 ES032029 United States ES NIEHS NIH HHS; UG3 OD023305 United States OD NIH HHS
    • Contributed Indexing:
      Keywords: Aminomethylphosphonic acid (AMPA); Birth cohort; Diet; Glyphosate; Pregnancy
    • Accession Number:
      TE7660XO1C (Glycine)
      4632WW1X5A (Glyphosate)
      0 (Herbicides)
      90825O5C1U (aminomethylphosphonic acid (AMPA))
      0 (Organophosphonates)
    • Publication Date:
      Date Created: 20241007 Date Completed: 20241127 Latest Revision: 20241130
    • Publication Date:
      20241202
    • Accession Number:
      PMC11602357
    • Accession Number:
      10.1016/j.envpol.2024.125083
    • Accession Number:
      39374760