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Immunomodulatory Biomaterials: Tailoring Surface Properties to Mitigate Foreign Body Reaction and Enhance Tissue Regeneration.
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- Author(s): Amani H;Amani H; Alipour M; Alipour M; Shahriari E; Shahriari E; Taboas JM; Taboas JM
- Source:
Advanced healthcare materials [Adv Healthc Mater] 2024 Nov; Vol. 13 (29), pp. e2401253. Date of Electronic Publication: 2024 Oct 06.- Publication Type:
Journal Article; Review- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE
- Publication Information: Original Publication: Weinheim : Wiley-VCH, 2012-
- Subject Terms:
- Abstract: The immune cells have demonstrated the ability to promote tissue repair by removing debris, breaking down the extracellular matrix, and regulating cytokine secretion profile. If the behavior of immune cells is not well directed, chronic inflammation and foreign body reaction (FBR) will lead to scar formation and loss of biomaterial functionality. The immunologic response toward tissue repair or chronic inflammation after injury and implantation can be modulated by manipulating the surface properties of biomaterials. Tailoring surface properties of biomaterials enables the regulation of immune cell fate such as adhesion, proliferation, recruitment, polarization, and cytokine secretion profile. This review begins with an overview of the role of immune cells in tissue healing and their interactions with biomaterials. It then discusses how the surface properties of biomaterials influence immune cell behavior. The core focus is reviewing surface modification methods to create innovative materials that reduce foreign body reactions and enhance tissue repair and regeneration by modulating immune cell activities. The review concludes with insights into future advancements in surface modification techniques and the associated challenges.
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- Accession Number: 0 (Biocompatible Materials)
- Publication Date: Date Created: 20241007 Date Completed: 20241122 Latest Revision: 20241203
- Publication Date: 20241204
- Accession Number: 10.1002/adhm.202401253
- Accession Number: 39370571
- Source:
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