Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion.

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  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: United States NLM ID: 101274889 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-3890 (Electronic) Linking ISSN: 15733882 NLM ISO Abbreviation: Metabolomics Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York : Springer, c2006-
    • Subject Terms:
      Methylamines*/metabolism ; Choline*/metabolism ; Exercise*/physiology; Humans ; Male ; Adult ; Young Adult ; Female ; Gastrointestinal Microbiome/physiology
    • Abstract:
      Introduction: Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown.
      Objectives/methods: This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort.
      Results: Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period.
      Conclusion: This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.
      (© 2024. The Author(s).)
    • References:
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    • Contributed Indexing:
      Keywords: Biomarker; Cardioprotection; Cardiovascular Risk; Exercise; Gut Microbiome; Nutrition
    • Accession Number:
      0 (Methylamines)
      FLD0K1SJ1A (trimethyloxamine)
      N91BDP6H0X (Choline)
    • Publication Date:
      Date Created: 20241005 Date Completed: 20241005 Latest Revision: 20241021
    • Publication Date:
      20241021
    • Accession Number:
      PMC11455687
    • Accession Number:
      10.1007/s11306-024-02177-0
    • Accession Number:
      39369155