Comparative transcatheter occlusion of patent ductus arteriosus: multicenter collaborative study across pediatric and veterinary cardiology centers.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101163270 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-0834 (Electronic) Linking ISSN: 17602734 NLM ISO Abbreviation: J Vet Cardiol Subsets: MEDLINE
    • Publication Information:
      Publication: <2005->: Amsterdam : Elsevier
      Original Publication: Bern, Switzerland : European Society of Veterinary Cardiology
    • Subject Terms:
      Ductus Arteriosus, Patent*/veterinary ; Ductus Arteriosus, Patent*/therapy ; Ductus Arteriosus, Patent*/surgery ; Dog Diseases*/therapy ; Cardiac Catheterization*/veterinary; Animals ; Dogs ; Retrospective Studies ; Male ; Female ; Child ; Humans ; Cohort Studies ; Child, Preschool ; Septal Occluder Device/veterinary ; Treatment Outcome
    • Abstract:
      Introduction/objective: Transcatheter therapeutics have revolutionized treatment of patent ductus arteriosus (PDA). Greater understanding of corrective interventions across species can advance best practices, protocols, and outcomes while minimizing adverse events. The objective of this study was to describe characteristics and outcomes in children and dogs undergoing transcatheter PDA occlusion.
      Animals, Materials and Methods: This was a multicenter, retrospective cohort study from two pediatric and three veterinary centers. Demographics, procedural characteristics, and outcomes were assessed.
      Results: Data included 202 children and 106 dogs treated from July 2019 to June 2021. Forty-five (23%) children and 19 (18%) dogs had congestive heart failure prior to catheterization. Transvenous and transarterial approaches for deployment were most used in children and dogs, respectively. All children had percutaneous vascular access compared to 17 (16%) dogs. Intraprocedural anticoagulation was standard for children (100% of 165 reported), but not for dogs (2/103). The median (interquartile range) pulmonary ostium diameter in children was 2.2 mm (1.5-3.0 mm) and 3.0 mm (2.0-4.2 mm) in dogs when all body sizes were considered (P<0.001). Amplatzer™ Duct Occluder was most commonly used in children (64/202, 32%); the Amplatz® Canine Duct Occluder was used in dogs (96/100, 96%). Closure was manual compression in all children, whereas vessel ligation was most used in dogs (74/104, 73%). Successful device deployment was achieved in 197 (98%) children and 98 (93%) dogs (P=0.03). Major reasons for failure included device embolization in six (2.9%) children and PDA morphology concerns in four (3.8%) dogs.
      Conclusions: Transcatheter PDA occlusion is successful in children and dogs. Study data might be useful for optimizing transcatheter therapeutics and animal models for interventional cardiology.
      Competing Interests: Conflict of Interest Statement The authors do not have any conflicts of interest to disclose.
      (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Animal model; Canine; Children; Interventional; PDA
    • Publication Date:
      Date Created: 20241002 Date Completed: 20241212 Latest Revision: 20241212
    • Publication Date:
      20241213
    • Accession Number:
      10.1016/j.jvc.2024.08.008
    • Accession Number:
      39357082