The effect of benzylpenicillin prohylaxis after birth on length and weight of syphilis-exposed infants in eastern China.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101510759 Publication Model: Electronic Cited Medium: Internet ISSN: 1824-7288 (Electronic) Linking ISSN: 17208424 NLM ISO Abbreviation: Ital J Pediatr Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central
    • Subject Terms:
      Infectious Disease Transmission, Vertical*/prevention & control ; Anti-Bacterial Agents*/therapeutic use ; Syphilis, Congenital*/prevention & control ; Body Weight* ; Body Height* ; Penicillin G*/administration & dosage; Humans ; Female ; China/epidemiology ; Male ; Infant, Newborn ; Infant ; Syphilis/drug therapy ; Pregnancy ; Pregnancy Complications, Infectious
    • Abstract:
      Background: We conducted this study to assess the impact of an intervention to interrupt mother-to-child transmission on the height and weight of syphilis-exposed infants after receiving penicillin prophylaxis after birth and to provide a scientific basis for further elimination of mother-to-child transmission.
      Methods: We recruited 419 infants born to syphilis-infected mothers from 2015 to 2020 in Changzhou, and performed 1:1 matching to infants born to syphilis-free mothers during the same period. All infants were followed up to 18 months of age. We collected height and weight data and compared them.
      Results: At 18 months of age, the height and weight of the syphilis-exposed infants were almost greater than the WHO reference standards. However, when compared with local unexposed infants, there were almost no differences. The boys born to mothers who received two courses of treatment had longer body lengths at 18 months of age than did those born to mothers who did not receive two courses of treatment, and the girls born to mothers who did not receive treatment had lower body weights at 3 months of age than did both treated groups.
      Conclusion: The growth trajectory of infants without congenital syphilis born to syphilis-infected mothers is virtually indistinguishable from that of the general local population. Syphilis-exposed newborns can receive preventive treatment as a public health intervention.
      (© 2024. The Author(s).)
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    • Grant Information:
      PMTCT201904 China Association for the Preventionand Control of STDs and AIDS• AbbVie Fund for Maternaland Child Care and Prevention of Mother-to-Child Transmission; CZQM2020101 Changzhou Health Young Cultivation Project; NMUB20220199 Nanjing Medical University Science and Technology Development Fund; 2023 Changzhou Longcheng Talent Program-Youth Science and Technology Talent Support Project 2023 Changzhou Longcheng Talent Program-Youth Science and Technology Talent Support Project
    • Contributed Indexing:
      Keywords: Body Weight; Body height; East Asian people; Infant; Penicillin G Benzathine; Syphilis
    • Accession Number:
      0 (Anti-Bacterial Agents)
      Q42T66VG0C (Penicillin G)
    • Publication Date:
      Date Created: 20240928 Date Completed: 20240928 Latest Revision: 20240930
    • Publication Date:
      20240930
    • Accession Number:
      PMC11438286
    • Accession Number:
      10.1186/s13052-024-01779-7
    • Accession Number:
      39334470