Patterns of soil-transmitted helminth aggregation in the human host population after several years of intensive mass drug administration.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 7506129 Publication Model: Print Cited Medium: Internet ISSN: 1878-3503 (Electronic) Linking ISSN: 00359203 NLM ISO Abbreviation: Trans R Soc Trop Med Hyg Subsets: MEDLINE
    • Publication Information:
      Publication: 2013- : Oxford : Oxford University Press
      Original Publication: 1920- : London : Royal Society of Tropical Medicine and Hygiene
    • Subject Terms:
      Mass Drug Administration* ; Soil*/parasitology ; Ascaris lumbricoides* ; Ascariasis*/epidemiology ; Ascariasis*/prevention & control ; Ascariasis*/transmission ; Anthelmintics*/administration & dosage ; Anthelmintics*/therapeutic use ; Feces*/parasitology ; Parasite Egg Count*; Humans ; Animals ; Prevalence ; Female ; Child ; Helminthiasis/epidemiology ; Helminthiasis/transmission ; Helminthiasis/drug therapy ; Helminthiasis/prevention & control ; Male
    • Abstract:
      Background: Community-wide mass drug administration (cMDA) is known as an effective, albeit costly, control strategy for soil-transmitted helminth (STH) parasites. A better understanding of STH aggregation after many rounds of cMDA could help shape more cost-effective policies.
      Methods: This analysis uses data from the Geshiyaro project, aiming to break STH transmission by cMDA and water, sanitation and hygiene interventions. Ascaris lumbricoides infection prevalence is derived from egg count data and parasite aggregation is obtained by fitting a negative binomial distribution to the frequency distribution of faecal egg counts.
      Results: The relationship between parasite dispersion and infection prevalence is approximately linear. Parasite aggregation increases as infection prevalence decreases.
      Conclusions: A minority of individuals carry most parasites as prevalence decreases in the community. These individuals could be selectively targeted for repeated treatment.
      (© The Author(s) 2024. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.)
    • References:
      Lancet. 2017 Jan 21;389(10066):287-297. (PMID: 27979381)
      Trans R Soc Trop Med Hyg. 2024 May 1;118(5):304-312. (PMID: 37965994)
      Trans R Soc Trop Med Hyg. 2023 Jul 4;117(7):514-521. (PMID: 36939014)
      Lancet Infect Dis. 2016 Jul;16(7):838-846. (PMID: 26897109)
      Parasit Vectors. 2020 Jun 24;13(1):324. (PMID: 32580759)
      Trans R Soc Trop Med Hyg. 2022 Dec 2;116(12):1226-1229. (PMID: 35474017)
      Parasit Vectors. 2019 Oct 29;12(1):503. (PMID: 31665080)
      Adv Parasitol. 2016;94:133-198. (PMID: 27756454)
    • Grant Information:
      R-1805-02741 Children's Investment Fund Foundation
    • Contributed Indexing:
      Keywords: aggregation; mass drug administration; soil-transmitted helminths
    • Accession Number:
      0 (Soil)
      0 (Anthelmintics)
    • Publication Date:
      Date Created: 20240927 Date Completed: 20241212 Latest Revision: 20241215
    • Publication Date:
      20241215
    • Accession Number:
      PMC11638107
    • Accession Number:
      10.1093/trstmh/trae059
    • Accession Number:
      39328058