Herb-drug interaction study of Yiqi Fumai lyophilized injection (YQFM) on pharmacokinetics of aspirin, nifedipine, and clopidogrel in rats.

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  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: England NLM ID: 8610241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0801 (Electronic) Linking ISSN: 02693879 NLM ISO Abbreviation: Biomed Chromatogr Subsets: MEDLINE
    • Publication Information:
      Publication: 1990- : Chichester : Wiley
      Original Publication: London : Heyden & Son, c1986-1990
    • Subject Terms:
      Clopidogrel*/pharmacokinetics ; Clopidogrel*/pharmacology ; Drugs, Chinese Herbal*/pharmacokinetics ; Drugs, Chinese Herbal*/pharmacology ; Drugs, Chinese Herbal*/administration & dosage ; Drugs, Chinese Herbal*/chemistry ; Aspirin*/pharmacokinetics ; Aspirin*/pharmacology ; Aspirin*/chemistry ; Aspirin*/administration & dosage ; Herb-Drug Interactions* ; Rats, Sprague-Dawley* ; Nifedipine*/pharmacokinetics ; Nifedipine*/pharmacology ; Nifedipine*/administration & dosage; Animals ; Rats ; Male ; Cytochrome P-450 Enzyme System/metabolism ; Ticlopidine/analogs & derivatives ; Ticlopidine/pharmacokinetics ; Ticlopidine/pharmacology ; Ticlopidine/chemistry
    • Abstract:
      Yiqi Fumai lyophilized injection (YQFM), a compound traditional Chinese medicine prescription derived from "Sheng Mai Powder," is approved for the treatment of cardiovascular diseases. YQFM is usually prescribed in combination with some Western medicines to treat patients, such as aspirin, nifedipine, and clopidogrel. However, the herb-drug interactions (HDIs) of YQFM are still unclear. We determined the effect of YQFM on drug metabolism-related CYP450 enzymes by in vitro assays. And the effects of YQFM on the pharmacokinetics of aspirin, nifedipine, or clopidogrel were analyzed in rats, as well as the effect of YQFM on the prothrombin time of aspirin or clopidogrel, to evaluate the safety and efficacy of co-administration. Our study indicated that the clinical dose of YQFM did not significantly influence the relevant CYP450 isoenzymes. Besides, YQFM had no effect on the pharmacokinetics of aspirin, nifedipine, or clopidogrel single and multiple administrations in rats. In pharmacodynamics study, YQFM also had no impact on prothrombin time of aspirin or clopidogrel. Based on the results of pharmacogenomics, pharmacokinetics, and pharmacodynamics, the HDIs of YQFM have a good safety profile, and the combination with the above three drugs might have synergistic effects due to the different efficacy of YQFM-quality markers.
      (© 2024 John Wiley & Sons Ltd.)
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    • Grant Information:
      H2023209001 Natural Science Foundation of Hebei Province; H2022209064 Natural Science Foundation of Hebei Province; 20231579 Medical Science Research Project of Hebei Province; ZYBZH-C-TJ-55 National Project for Standardization of Chinese Materia Medica
    • Contributed Indexing:
      Keywords: Yiqi Fumai lyophilized injection; aspirin; clopidogrel; herb–drug interactions; nifedipine; pharmacogenomics; pharmacokinetics
    • Accession Number:
      A74586SNO7 (Clopidogrel)
      0 (Drugs, Chinese Herbal)
      R16CO5Y76E (Aspirin)
      I9ZF7L6G2L (Nifedipine)
      9035-51-2 (Cytochrome P-450 Enzyme System)
      OM90ZUW7M1 (Ticlopidine)
    • Publication Date:
      Date Created: 20240926 Date Completed: 20241117 Latest Revision: 20241117
    • Publication Date:
      20241118
    • Accession Number:
      10.1002/bmc.6018
    • Accession Number:
      39327227